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首页> 外文期刊>Pediatric blood & cancer >Associations between neutrophil recovery time, infections and relapse in pediatric acute myeloid leukemia
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Associations between neutrophil recovery time, infections and relapse in pediatric acute myeloid leukemia

机译：中性粒细胞恢复时间，感染和分泌儿科急性髓性白血病的关联

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Abstract Background Children with acute myeloid leukemia (AML) treated similarly show different toxicity and leukemic responses. We investigated associations between neutrophil recovery time after the first induction course, infection and relapse in children treated according to NOPHO‐AML 2004 and DB AML‐01. Procedure Newly diagnosed patients with AML with bone marrow blast?5% between day 15 after the start of the treatment and the start of second induction course, and in complete remission after the second induction course were included (n?=?279). Neutrophil recovery time was defined as the time from the start of the course to the last day with absolute neutrophil count?0.5?×?10 9 /l. Linear and Cox regressions were used to investigate associations. Results Neutrophil recovery time after the first induction course was positively associated with neutrophil recovery time after the remaining courses, and longer neutrophil recovery time (≥25 days) was associated with increased risk of grade 3–4 infections (hazard ratio 1.4, 95% confidence interval [CI], 1.1–1.8). Longer neutrophil recovery time after the first induction (30 days) was associated with the increased risk of relapse (5‐year cumulative incidence: 48% vs. 42%, hazard ratio 1.7, 95% CI, 1.1–2.6) for cases not treated with hematopoietic stem cell transplantation in first complete remission. Conclusion Longer neutrophil recovery time after the first induction course was associated with grade 3–4 infections and relapse. If confirmed, this knowledge could be incorporated into risk stratification strategies in pediatric AML.
机译：摘要背景儿童有急性髓性白血病（AML）的同样显示出不同的毒性和白血病反应。我们调查了根据Nopho-AML 2004和DB AML-01治疗的儿童感染和复发后中性粒细胞恢复时间之间的关联。手术新诊断患有骨髓爆炸的AML患者ααΔt，在第15天之间进行治疗后的第15天和第二次诱导过程开始，并且在包括第二种进疗过程后完全缓解（n？= 279） 。中性粒细胞恢复时间被定义为从课程开始到最后一天的时间，绝对中性粒细胞计数？<0.5？×10 9 / L.线性和Cox回归用于调查关联。结果中性粒细胞恢复时间在剩余的课程后第一个感应过程与中性粒粒度恢复时间呈正相关，较长的中性粒细胞恢复时间（≥25天）与3-4级感染的风险增加有关（危险比1.4,95％的信心间隔[CI]，1.1-1.8）。在第一个诱导（＆ 30天）后更长的中性粒细胞恢复时间与复发风险的增加有关（5年累积发病率：48％与42％，危险比1.7,95％CI，1.1-2.6）进行案件在首次完全缓解中没有用造血干细胞移植治疗。结论第一个诱导过程后较长的中性粒细胞恢复时间与3-4级感染和复发相关。如果确认，本知识可以纳入儿科AML的风险分层策略。

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  • 来源
    《Pediatric blood & cancer》 |2018年第9期|共8页
  • 作者

    L?hmann Ditte J. A.; Asdahl Peter H.; Abrahamsson Jonas; Ha Shau‐Yin; Jónsson ólafur G.; Kaspers Gertjan J. L.; Koskenvuo Minna; Lausen Birgitte; Moerloose Barbara; Palle Josefine; Zeller Bernward; Hasle Henrik;

  • 作者单位

    Department of Pediatrics and Adolescent MedicineAarhus University HospitalAarhus Denmark;

    Department of HematologyAarhus University HospitalAarhus Denmark;

    Institution for Clinical SciencesQueen Silvia Children's HospitalGothenburg Sweden;

    Department of PediatricsQueen Mary Hospital and Hong Kong Pediatric Hematology and Oncology Study;

    Department of PediatricsLandspitali University HospitalReykjavik Iceland;

    Department of PediatricsVU University Medical Center Amsterdam and Dutch Childhood Oncology;

    Division of Hematology‐Oncology and Stem Cell TransplantationUniversity of HelsinkiHelsinki Finland;

    Department of Pediatrics and Adolescent MedicineUniversity of CopenhagenCopenhagen Denmark;

    Department of PediatricsGhent University HospitalGhent Belgium;

    Department of Woman′s and Children′s HealthUppsala UniversityUppsala Sweden;

    Division of Pediatric and Adolescent MedicineOslo University HospitalOslo Norway;

    Department of Pediatrics and Adolescent MedicineAarhus University HospitalAarhus Denmark;

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  • 正文语种 eng
  • 中图分类 儿科学;
  • 关键词

    acute myeloid leukemia; infection; neutropenia; pediatric cancer; relapse;

    机译：急性髓性白血病;感染;中性粒细胞病;儿科癌症;复发;

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