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首页> 外文期刊>Pediatric blood & cancer >Is an infectious trigger always required for primary hemophagocytic lymphohistiocytosis? Lessons from in utero and neonatal disease
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Is an infectious trigger always required for primary hemophagocytic lymphohistiocytosis? Lessons from in utero and neonatal disease

机译：一直是一种传染性触发器，始终需要初级血糖淋巴管梗死症？ 来自子宫和新生儿疾病的课程

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摘要

Abstract In this report, we evaluate the hypothesis that hemophagocytic lymphohistiocytosis in patients with defects of lymphocyte cytotoxicity is usually triggered by infections. We show that in the majority of patients, extensive virus PCR panels performed in addition to routine microbiological investigations remain negative and summarize 25 patients with onset of hemophagocytic lymphohistiocytosis in utero or within the first 10 days of life, in none of which an associated bacterial or viral infection was reported. These observations, even though preliminary, invite to consider a key role of lymphocyte cytotoxicity in controlling T‐cell homeostasis also in the absence of apparent infectious stimuli.
机译：摘要在本报告中，我们评估了淋巴细胞细胞毒性缺陷患者血糖淋巴管引发症的假设通常通过感染引发。 我们表明，在大多数患者中，除了常规微生物调查外，还进行了广泛的病毒PCR面板仍然是负面的，并且总结25名患有子宫内血管性淋巴管引发症的患者，或者在生命的前10天内，任何一个相关的细菌或 报道了病毒感染。 这些观察结果，即使初步，旨在考虑淋巴细胞细胞毒性在控制T细胞稳态中的关键作用也没有明显的传染刺激。

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  • 来源
    《Pediatric blood & cancer》 |2018年第11期|共5页
  • 作者

    Heeg Maximilian; Ammann Sandra; Klemann Christian; Panning Marcus; Falcone Valeria; Hengel Harmut; Lehmberg Kai; zur Stadt Udo; Wustrau Katharina; Janka Gritta; Ehl Stephan;

  • 作者单位

    Center for Chronic ImmunodeficiencyMedical Center University of Freiburg Faculty of;

    Center for Chronic ImmunodeficiencyMedical Center University of Freiburg Faculty of;

    Center for Chronic ImmunodeficiencyMedical Center University of Freiburg Faculty of;

    Institute of Virology University Medical CenterAlbert‐Ludwigs‐University of FreiburgFreiburg;

    Institute of Virology University Medical CenterAlbert‐Ludwigs‐University of FreiburgFreiburg;

    Institute of Virology University Medical CenterAlbert‐Ludwigs‐University of FreiburgFreiburg;

    Department of Pediatric Hematology and OncologyUniversity Medical Center Hamburg‐EppendorfHamburg;

    Department of Pediatric Hematology and OncologyUniversity Medical Center Hamburg‐EppendorfHamburg;

    Department of Pediatric Hematology and OncologyUniversity Medical Center Hamburg‐EppendorfHamburg;

    Department of Pediatric Hematology and OncologyUniversity Medical Center Hamburg‐EppendorfHamburg;

    Center for Chronic ImmunodeficiencyMedical Center University of Freiburg Faculty of;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 儿科学;
  • 关键词

    hemophagocytic lymphohistiocytosis; immunodeficiencies; primary HLH;

    机译：血小杂细胞淋巴管激菌症;免疫缩小;主要HLH;

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