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首页> 外文期刊>Bioscience, Biotechnology, and Biochemistry >Optimization of 1-Deoxynojirimycin Extraction from Mulberry Leaves by Using Response Surface Methodology
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Optimization of 1-Deoxynojirimycin Extraction from Mulberry Leaves by Using Response Surface Methodology

机译：响应面法优化桑叶中1-脱氧野rim霉素的提取工艺

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摘要

Mulberry 1-deoxynojirimycin (DNJ, a potent α-glycosidase inhibitor) has therapeutic potency against diabetes mellitus. However, the amount of DNJ in mulberry leaves is low (about 0.1%), and a more effective extraction method is needed. Ultrasound-assisted extraction (UAE) was applied in this study for mulberry DNJ extraction, and five factors, the percentage of ethanol in the extraction solvent (x_1), ratio of the extraction solvent to mulberry sample (x_2), ultrasonic power (x_3), extraction temperature (x_4) and extraction time (xs), were investigated by fractional factorial 2~(5-1) design (FFD) to obtain the optimum extraction efficiency (DNJ yield, Y_1) and extraction productivity (total yield, y_2). The results showed that x_2, x_3 and x_5 had significant impact on Y_1 and Y_2, and were further optimized by response surface methodology (RSM). Under the optimized conditions (x_2, x_3 and x_5 of 7 ml/g, 180 W and 260 s, respectively), DNJ-enriched powder (0.8%) was produced with high extraction efficiency (98%) and productivity (20%), enabling this product to be used for nutraceutical purposes.
机译：桑树1-脱氧野oji霉素（DNJ，有效的α-糖苷酶抑制剂）对糖尿病具有治疗作用。但是，桑叶中DNJ的含量低（约0.1％），需要更有效的提取方法。本研究采用超声波辅助萃取技术提取桑DNJ，其中五个因素为乙醇在萃取溶剂中的比例（x_1），萃取溶剂与桑树样品的比例（x_2），超声功率（x_3）。通过分数阶乘2〜（5-1）设计（FFD）研究了提取温度（x_4）和提取时间（xs），以获得最佳提取效率（DNJ产量，Y_1）和提取生产率（总产量，y_2） 。结果表明，x_2，x_3和x_5对Y_1和Y_2有显着影响，并通过响应面方法（RSM）进行了进一步优化。在最佳条件下（x_2，x_3和x_5分别为7 ml / g，180 W和260 s），生产的DNJ含量高的粉末（0.8％）具有较高的提取效率（98％）和生产率（20％），使该产品可用于营养保健用途。

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