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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Hearing Loss With Congenital Cytomegalovirus Infection
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Hearing Loss With Congenital Cytomegalovirus Infection

机译：与先天性细胞病毒感染的听力丧失

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OBJECTIVE: In this study, we determined the prevalence of hearing loss in 157 children with proven congenital cytomegalovirus (cCMV) infection. We looked at possible risk determinants for developing hearing loss and proposed recommendations for screening and follow-up in the newborn. METHODS: In a prospective 22-year study, 157 children with proven cCMV infection were evaluated for sensorineural hearing loss (SNHL). The development of SNHL was correlated with the type of maternal infection (primary versus nonprimary), the gestational age of maternal primary infection, imaging findings at birth, and the presence of symptomatic or asymptomatic infection in the newborn. RESULTS: Of all children, 12.7% had SNHL, and 5.7% needed hearing amplification because of SNHL. Improvement, progression, and fluctuations of hearing thresholds were seen in 45%, 53.8%, and 5.7% of the children, respectively. Hearing loss was more common in the case of a symptomatic infection at birth (P = .017), after a maternal primary infection in the first trimester of pregnancy (P = .029), and in the presence of abnormalities on a neonatal brain ultrasound and/or MRI (P < .001). CONCLUSION SNHL is a common sequela in children with cCMV infection. Risk factors for SNHL were primary maternal infections before the 14th week of pregnancy, the presence of a disseminated infection at birth, and imaging abnormalities in the newborn. These children may benefit from a more thorough investigation for SNHL than children who do not present with those risk factors.
机译：目的：在这项研究中，我们确定了157名儿童听力损失的患病率，并经过验证的先天性细胞病毒（CCMV）感染。我们寻找可能的风险决定因素，用于制定审理损失和拟议的筛选和后续行动建议。方法：在预期22年的研究中，对感觉文体听力损失（SNHL）评估了157例具有证明CCMV感染的儿童。 SNHL的发展与母体感染类型（初级与非孕丙），孕产妇原发性感染，出生中的成像结果以及新生儿症状或无症状感染的类型相关。结果：所有儿童，12.7％有SNHL，5.7％，因为SNHL为5.7％的听力放大。分别在45％，53.8％和5.7％的儿童中看到了听力阈值的改进，进展和波动。在妊娠第一个三个月（P = 0.029）的母体原发性感染后，听力损失更常见于出生（p = .017）后（p = .029），并且在新生脑超声的异常存在下和/或MRI（p <.001）。结论SNHL是CCMV感染儿童的常见后遗症。 SNHL的危险因素是怀孕第14周之前的原发性母体感染，在出生时出现逾期感染，以及新生儿的成像异常。这些儿童可以从更彻底的SNHL调查，而不是那些不存在这些风险因素的儿童。

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