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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Cardiometabolic Risk and Body Composition in Youth With Down Syndrome
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Cardiometabolic Risk and Body Composition in Youth With Down Syndrome

机译：唐氏综合征的青春的心脏素风险和身体组成

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BACKGROUND AND OBJECTIVES: Whether BMI captures adiposity and cardiometabolic risk in Down syndrome (DS), a condition associated with obesity, short stature, and altered body proportions, is not known. We compared cardiometabolic risk measures in youth with DS and typically developing matched controls. METHODS: Youth with (n = 150) and without (n = 103) DS of comparable age (10-20 years), sex, race, ethnicity, and BMI percentile underwent whole-body dual-energy X-ray absorptiometry, fasting glucose, insulin, lipids, lipoprotein particles, inflammatory factors, and when BMI percentile >= 85, an oral glucose tolerance test. RESULTS: Sixty-four percent of youth with DS had BMI percentile >= 85. Among these, no difference in glucose, insulin, or insulin resistance was detected, but prediabetes was more prevalent with DS (26.4% vs 10.3%; P = .025) after adjustment for demographics, pubertal status, and BMI z score (odds ratio = 3.2; P = .026). Among all participants, those with DS had higher low-density lipoprotein cholesterol (median 107 [interquartile range 89-128] vs 88.5 [79-103] mg/dL; P < .00005), triglycerides (89.5 [73-133] vs 71.5 [56-104] mg/dL; P < .00005), non-high-density lipoprotein cholesterol (non-HDL-C; 128 [104-153] vs 107 [92-123] mg/dL; P < .00005), and triglycerides/HDL-C (2.2 [1.6-3.4] vs 1.7 [1.1-2.5] mg/dL; P = .0003) and lower levels of HDL-C (41 [36.5-47] vs 45 [37-53] mg/dL; P = .012). DS youth had higher high-sensitivity C-reactive protein, interleukin-6, small low-density lipoprotein particles (LDL-P), and total LDL-P, but similar LDL-P size. Youth with DS had less visceral fat (VFAT), fat mass, and lean mass for BMI z score, but greater VFAT at higher fat mass. However, VFAT did not fully explain the increased prevalence of dyslipidemia or prediabetes in youth with DS. CONCLUSIONS: Despite similar insulin resistance, youth with DS had greater prevalence of dyslipidemia and prediabetes than typically developing youth, which was not fully explained by VFAT.
机译：背景和目标：BMI是否捕获令人厌恶综合征（DS）的肥胖和心脏异构风险，与肥胖，短地和身体比例改变的病症是不名的。我们将青少年的心脏异构风险措施与DS进行比较，通常开发匹配的控制。方法：FOYTH与（n = 150），没有（n = 103）可比年龄（10-20岁），性别，种族，种族和BMI百分位接受全身双能X射线吸收测量，空腹葡萄糖，胰岛素，脂质，脂蛋白颗粒，炎症因子，当BMI百分位数> = 85时，口服葡萄糖耐量试验。结果：64％的青少年与DS有BMI百分位> = 85.其中，检测到葡萄糖，胰岛素或胰岛素抵抗的差异，但Pregiabetes与DS普遍普遍（26.4％Vs 10.3％; P =。 025）调整人口统计数据，青春期状态和BMI Z得分（差价率= 3.2; p = .026）。在所有参与者中，DS的那些具有较高的低密度脂蛋白胆固醇（中位数107 [四分位数89-128] Vs 88.5 [79-103] Mg / D1; P <.00005），甘油三酯（89.5 [73-133] Vs 71.5 [56-104] Mg / dL; p <.00005），非高密度脂蛋白胆固醇（非HDL-C; 128 [104-153] Vs 107 [92-123] mg / dl; p <。 00005）和甘油三酯/ HDL-C（2.2 [1.6-3.4]与1.7 [1.1-2.5] Mg / dL; P = .0003）和低水平的HDL-C（41 [36.5-47] Vs 45 [37 [37] -53] mg / dl; p = .012）。 DS青少年具有较高的高灵敏度C-反应蛋白，白细胞介素-6，小低密度脂蛋白颗粒（LDL-P），以及总LDL-P，但类似的LDL-P尺寸。 BMI Z得分的含有DS的青少年脂肪（VFAT），脂肪质量和瘦肉质量，但脂肪质量较高的VFAT。然而，VFAT没有完全解释与DS中青少年血脂血症或前脂蛋白酶的患病率增加。结论：尽管具有相似的胰岛素抵抗力，但DS的青少年患有血脂血症和前脂肪的患病率比通常发展青年患者常见于VFAT不完全解释。

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