...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >The risk of immune thrombocytopenic purpura after vaccination in children and adolescents.
【24h】

The risk of immune thrombocytopenic purpura after vaccination in children and adolescents.

机译：儿童和青少年疫苗接种后免疫血小板细胞丙戊胡的风险。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: The risk of immune thrombocytopenic purpura (ITP) after childhood vaccines other than measles-mumps-rubella vaccine (MMR) is unknown. METHODS: Using data from 5 managed care organizations for 2000 to 2009, we identified a cohort of 1.8 million children ages 6 weeks to 17 years. Potential ITP cases were identified by using diagnostic codes and platelet counts. All cases were verified by chart review. Incidence rate ratios were calculated comparing the risk of ITP in risk (1 to 42 days after vaccination) and control periods. RESULTS: There were 197 chart-confirmed ITP cases out of 1.8 million children in the cohort. There was no elevated risk of ITP after any vaccine in early childhood other than MMR in the 12- to 19-month age group. There was a significantly elevated risk of ITP after hepatitis A vaccine at 7 to 17 years of age, and for varicella vaccine and tetanus-diphtheria-acellular pertussis vaccine at 11 to 17 years of age. For hepatitis A, varicella, and tetanus-diphtheria-acellular pertussis vaccines, elevated risks were based on one to two vaccine-exposed cases. Most cases were acute and mild with no long-term sequelae. CONCLUSIONS: ITP is unlikely after early childhood vaccines other than MMR. Because of the small number of exposed cases and potential confounding, the possible association of ITP with hepatitis A, varicella, and tetanus-diphtheria-acellular pertussis vaccines in older children requires further investigation.
机译：背景：除麻疹 - 腮腺炎 - 风疹疫苗（MMR）以外的儿童疫苗（MMR）之外的儿童疫苗后免疫血小板细胞发作紫癜（ITP）的风险是未知的。方法：采用2000年至2009年的5个管理护理组织的数据，我们确定了6周至17岁的180万岁儿童的队列。通过使用诊断代码和血小板计数来识别潜在的ITP病例。所有病例均按图表审查验证。分析率比将ITP风险的风险进行比较（疫苗接种后1至42天）和控制期。结果：197种图表确认的ITP案件在队列中的180万儿童中。在12至19个月年龄组的MMR以外的童年早期的任何疫苗后，ITP风险没有升高。甲型肝炎疫苗在7至17岁的疫苗和Tetanus-Diphtheria-Acellulary患者疫苗11至17岁，甲型肝炎后ITP风险显着提高。对于乙型肝炎，水痘和破伤风 - 白喉 - 无细胞疫苗疫苗，升高的风险基于一对一的疫苗暴露病例。大多数病例均为急性和轻度，没有长期的后遗症。结论：在MMR以外的早期儿童疫苗后，ITP不太可能。由于少量的暴露病例和潜在的混淆，ITP与甲型肝炎的可能协会，年龄较大的儿童中的ITP和Tetanus-Diphtheria-患有疫苗疫苗需要进一步调查。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号