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首页> 外文期刊>Physics in medicine and biology. >Monte Carlo modelling of photodynamic therapy treatments comparing clustered three dimensional tumour structures with homogeneous tissue structures
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Monte Carlo modelling of photodynamic therapy treatments comparing clustered three dimensional tumour structures with homogeneous tissue structures

机译：光动力治疗治疗的蒙特卡罗建模与均匀组织结构进行聚类三维肿瘤结构

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摘要

We explore the effects of three dimensional (3D) tumour structures on depth dependent fluence rates, photodynamic doses (PDD) and fluorescence images through Monte Carlo radiation transfer modelling of photodynamic therapy. The aim with this work was to compare the commonly used uniform tumour densities with non-uniform densities to determine the importance of including 3D models in theoretical investigations. It was found that fractal 3D models resulted in deeper penetration on average of therapeutic radiation and higher PDD. An increase in effective treatment depth of 1 mm was observed for one of the investigated fractal structures, when comparing to the equivalent smooth model. Wide field fluorescence images were simulated, revealing information about the relationship between tumour structure and the appearance of the fluorescence intensity. Our models indicate that the 3D tumour structure strongly affects the spatial distribution of therapeutic light, the PDD and the wide field appearance of surface fluorescence images.
机译：我们探讨了三维（3D）肿瘤结构对深度依赖性的能量率，光动力剂量（PDD）和荧光图像通过光动力学治疗的蒙特卡罗辐射转移模拟。该工作的目的是将常用的统一肿瘤密度与非均匀密度进行比较，以确定包括3D模型在理论调查中的重要性。发现分形3D模型导致平均治疗辐射和更高的PDD平均渗透。当与等效的平滑模型相比，对于其中一个研究的分形结构观察到有效处理深度的有效处理深度的增加。模拟宽场荧光图像，揭示了关于肿瘤结构与荧光强度外观之间的关系的信息。我们的模型表明3D肿瘤结构强烈影响治疗光的空间分布，PDD和表面荧光图像的宽场外观。

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