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首页> 外文期刊>Physics in medicine and biology. >Monte Carlo modelling of photodynamic therapy treatments comparing clustered three dimensional tumour structures with homogeneous tissue structures
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Monte Carlo modelling of photodynamic therapy treatments comparing clustered three dimensional tumour structures with homogeneous tissue structures

机译：蒙特卡洛光动力学疗法的建模比较了簇状三维肿瘤结构与均质组织结构的比较

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摘要

We explore the effects of three dimensional (3D) tumour structures on depth dependent fluence rates, photodynamic doses (PDD) and fluorescence images through Monte Carlo radiation transfer modelling of photodynamic therapy. The aim with this work was to compare the commonly used uniform tumour densities with non-uniform densities to determine the importance of including 3D models in theoretical investigations. It was found that fractal 3D models resulted in deeper penetration on average of therapeutic radiation and higher PDD. An increase in effective treatment depth of 1 mm was observed for one of the investigated fractal structures, when comparing to the equivalent smooth model. Wide field fluorescence images were simulated, revealing information about the relationship between tumour structure and the appearance of the fluorescence intensity. Our models indicate that the 3D tumour structure strongly affects the spatial distribution of therapeutic light, the PDD and the wide field appearance of surface fluorescence images.
机译：我们通过光动力疗法的蒙特卡洛辐射转移模型探索了三维（3D）肿瘤结构对依赖深度的注量率，光动力剂量（PDD）和荧光图像的影响。这项工作的目的是比较常用的均匀肿瘤密度和不均匀密度，以确定在理论研究中包括3D模型的重要性。发现分形3D模型导致平均平均更深的治疗放射线渗透和更高的PDD。与等效的光滑模型相比，对于一种研究的分形结构，观察到有效处理深度增加了1 mm。模拟了宽视场荧光图像，揭示了有关肿瘤结构与荧光强度外观之间关系的信息。我们的模型表明3D肿瘤结构强烈影响治疗光的空间分布，PDD和表面荧光图像的宽视场外观。

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