...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Physics in medicine and biology. >Characterisation of a phantom for multiwavelength quantitative photoacoustic imaging
【24h】

Characterisation of a phantom for multiwavelength quantitative photoacoustic imaging

机译：用于多波长定量光声成像的幻像的表征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Quantitative photoacoustic imaging (qPAI) has the potential to provide high-resolution in vivo images of chromophore concentration, which may be indicative of tissue function and pathology. Many strategies have been proposed recently for extracting quantitative information, but many have not been experimentally verified. Experimental phantom-based validation studies can be used to test the robustness and accuracy of such algorithms in order to ensure reliable in vivo application is possible. The phantoms used in such studies must have well-characterised optical and acoustic properties similar to tissue, and be versatile and stable. Polyvinyl chloride plastisol (PVCP) has been suggested as a phantom for quality control and system evaluation. By characterising its multiwavelength optical properties, broadband acoustic properties and thermoelastic behaviour, this paper examines its potential as a phantom for qPAI studies too. PVCP's acoustic properties were assessed for various formulations, as well as its intrinsic optical absorption, and scattering with added TiO2, over a range of wavelengths from 400-2000 nm. To change the absorption coefficient, pigment-based chromophores that are stable during the phantom fabrication process, were used. These yielded unique spectra analogous to tissue chromophores and linear with concentration. At the high peak powers typically used in photoacoustic imaging, nonlinear optical absorption was observed. The Gruneisen parameter was measured to be Gamma = 1.01 +/- 0.05, larger than typically found in tissue, though useful for increased PA signal. Single and multiwavelength 3D PA imaging of various fabricated PVCP phantoms were demonstrated.
机译：定量光声成像（QPAI）具有在发色团浓度的体内图像中提供高分辨率，这可能表明组织功能和病理学。最近提出了许多策略来提取量化信息，但许多人尚未经过实验验证。基于实验幻像的验证研究可用于测试这种算法的鲁棒性和准确性，以确保在体内应用中可靠。在这些研究中使用的幻像必须具有与组织类似的光学和声学性质，并且具有通用和稳定性。已经提出了聚氯乙烯促溶溶胶（PVCP）作为质量控制和系统评估的幻像。通过表征其多波长光学性质，宽带声学特性和热弹性行为，本文将其视为QPAI研究的幻象。对于各种配方，以及其固有光学吸收和添加TiO 2的散射，在400-2000nm的波长范围内评估PVCP的声学性质。为了改变吸收系数，使用稳定在幻像制造过程中稳定的基于颜料的发色团。这些产生独特的光谱，类似于组织发色团和用浓度线性。在通常用于光声成像的高峰功率，观察到非线性光学吸收。测量Gruneisen参数γ= 1.01 +/- 0.05，比通常在组织中发现的γ= 1.01 +/- 0.05，但对于增加的PA信号有用。证明了各种制造的PVCP幽灵的单波长和多波长3D PA成像。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号