...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Physics in medicine and biology. >A 32 mm x 32 mm x 22 mm monolithic LYSO:Ce detector with dual-sided digital photon counter readout for ultrahigh-performance TOF-PET and TOF-PET/MRI
【24h】

A 32 mm x 32 mm x 22 mm monolithic LYSO:Ce detector with dual-sided digital photon counter readout for ultrahigh-performance TOF-PET and TOF-PET/MRI

机译：一个32 mm x 32 mm x 22 mm单片Lyso：CE检测器，带双面数字光子计数器读出超高性能TOF-PET和TOF-PET / MRI

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

New applications for positron emission tomography (PET) and combined PET/magnetic resonance imaging (MRI) are currently emerging, for example in the fields of neurological, breast, and pediatric imaging. Such applications require improved image quality, reduced dose, shorter scanning times, and more precise quantification. This can be achieved by means of dedicated scanners based on ultrahigh-performance detectors, which should provide excellent spatial resolution, precise depth-of-interaction (DOI) estimation, outstanding time-of-flight (TOF) capability, and high detection efficiency. Here, we introduce such an ultrahigh-performance TOF/DOI PET detector, based on a 32 mm x 32 mm x 22 mm monolithic LYSO: Ce crystal. The 32 mm x 32 mm front and back faces of the crystal are coupled to a digital photon counter (DPC) array, in so-called dual-sided readout (DSR) configuration. The fully digital detector offers a spatial resolution of similar to 1.1 mm full width at half maximum (FWHM)/similar to 1.2 mm mean absolute error, together with a DOI resolution of similar to 2.4 mm FWHM, an energy resolution of 10.2% FWHM, and a coincidence resolving time of 147 ps FWHM. The time resolution closely approaches the best results (135 ps FWHM) obtained to date with small crystals made from the same material coupled to the same DPC arrays, illustrating the excellent correction for optical and electronic transit time spreads that can be achieved in monolithic scintillators using maximum-likelihood techniques for estimating the time of interaction. The performance barely degrades for events with missing data ( up to 6 out of 32 DPC dies missing), permitting the use of almost all events registered under realistic acquisition conditions. Moreover, the calibration procedures and computational methods used for position and time estimation follow recently made improvements that make them fast and practical, opening up realistic perspectives for using DSR monolithic scintillator detectors in TOF-PET and TOF-PET/MRI systems.
机译：目前正在出现正电子发射断层扫描（PET）和组合的PET /磁共振成像（MRI）的新应用，例如在神经系统，乳房和儿科成像领域。这些应用需要改善的图像质量，减少剂量，较短的扫描时间，更精确的量化。这可以通过基于超高性能探测器的专用扫描仪来实现，这应该提供出色的空间分辨率，精确的相互作用（DOI）估计，出色的飞行时间（TOF）能力和高检测效率。在这里，我们介绍了这种超高性能TOF / DOI PET检测器，基于32mm x 32 mm x 22 mm整体式LYSO：CE晶体。晶体的32mm×32mm正面和背面耦合到数字光子计数器（DPC）阵列，在所谓的双面读数（DSR）配置中。完全数字检测器提供类似于1.1毫米的空间分辨率为1.1毫米的全宽（FWHM）/类似于1.2 mm平均绝对误差，与2.4 mm FWHM的DOI分辨率一起，能量分辨率为10.2％FWHM，和巧合解时间为147 ps fwhm。时间分辨率与迄今为止的迄今获得的最佳结果（135 ps fwhm）与由耦合到相同DPC阵列的相同材料制成的小晶体，示出了可以在单片闪烁体中实现的光学和电子传输时间差的优异校正用于估计交互时间的最大似然技术。对于缺失数据的事件的表现几乎没有降低（最多6个中缺少32个DPC死亡），允许使用在现实收购条件下注册的几乎所有事件。此外，用于位置和时间估计的校准程序和计算方法遵循最近使得改进，使其快速实用，开辟了在TOF-PET和TOF-PET / MRI系统中使用DSR单片闪烁体探测器的现实视角。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号