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首页> 外文期刊>Physics in medicine and biology. >A 32 mm x 32 mm x 22 mm monolithic LYSO:Ce detector with dual-sided digital photon counter readout for ultrahigh-performance TOF-PET and TOF-PET/MRI
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A 32 mm x 32 mm x 22 mm monolithic LYSO:Ce detector with dual-sided digital photon counter readout for ultrahigh-performance TOF-PET and TOF-PET/MRI

机译：具有双面数字光子计数器读数的32 mm x 32 mm x 22 mm整体式LYSO：Ce检测器，用于超高性能TOF-PET和TOF-PET / MRI

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摘要

New applications for positron emission tomography (PET) and combined PET/magnetic resonance imaging (MRI) are currently emerging, for example in the fields of neurological, breast, and pediatric imaging. Such applications require improved image quality, reduced dose, shorter scanning times, and more precise quantification. This can be achieved by means of dedicated scanners based on ultrahigh-performance detectors, which should provide excellent spatial resolution, precise depth-of-interaction (DOI) estimation, outstanding time-of-flight (TOF) capability, and high detection efficiency. Here, we introduce such an ultrahigh-performance TOF/DOI PET detector, based on a 32 mm x 32 mm x 22 mm monolithic LYSO: Ce crystal. The 32 mm x 32 mm front and back faces of the crystal are coupled to a digital photon counter (DPC) array, in so-called dual-sided readout (DSR) configuration. The fully digital detector offers a spatial resolution of similar to 1.1 mm full width at half maximum (FWHM)/similar to 1.2 mm mean absolute error, together with a DOI resolution of similar to 2.4 mm FWHM, an energy resolution of 10.2% FWHM, and a coincidence resolving time of 147 ps FWHM. The time resolution closely approaches the best results (135 ps FWHM) obtained to date with small crystals made from the same material coupled to the same DPC arrays, illustrating the excellent correction for optical and electronic transit time spreads that can be achieved in monolithic scintillators using maximum-likelihood techniques for estimating the time of interaction. The performance barely degrades for events with missing data ( up to 6 out of 32 DPC dies missing), permitting the use of almost all events registered under realistic acquisition conditions. Moreover, the calibration procedures and computational methods used for position and time estimation follow recently made improvements that make them fast and practical, opening up realistic perspectives for using DSR monolithic scintillator detectors in TOF-PET and TOF-PET/MRI systems.
机译：正电子发射断层扫描（PET）和组合式PET /磁共振成像（MRI）的新应用目前正在兴起，例如在神经，乳房和儿科成像领域。此类应用需要改进的图像质量，减少的剂量，较短的扫描时间和更精确的定量。这可以通过基于超高性能检测器的专用扫描仪来实现，该扫描仪应提供出色的空间分辨率，精确的相互作用深度（DOI）估计，出色的飞行时间（TOF）能力和高检测效率。在这里，我们介绍一种基于32 mm x 32 mm x 22 mm整体式LYSO：Ce晶体的超高性能TOF / DOI PET检测器。晶体的32 mm x 32 mm的正面和背面以所谓的双面读取（DSR）配置耦合到数字光子计数器（DPC）阵列。全数字检测器提供的空间分辨率类似于半峰全宽（FWHM）1.1毫米/平均绝对误差约为1.2毫米，DOI分辨率类似于2.4毫米FWHM，能量分辨率为10.2％FWHM，重合时间为147 ps FWHM。时间分辨率接近于迄今为止的最佳结果（135 ps FWHM），该结果是由用相同材料耦合到相同DPC阵列制成的小晶体制成的，这说明在单片闪烁体中，通过使用用于估计交互时间的最大似然技术。对于缺少数据的事件，性能几乎不会降低（在32个DPC晶粒中最多有6个丢失），从而允许使用在实际采集条件下注册的几乎所有事件。此外，用于位置和时间估计的校准程序和计算方法紧随最近进行了改进，使其快速，实用，为在TOF-PET和TOF-PET / MRI系统中使用DSR单片闪烁体探测器打开了现实的前景。

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