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MR-based source localization for MR-guided HDR brachytherapy

机译：MR-Puid HDR近距离放射治疗的先生源定位

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摘要

For the purpose of MR-guided high-dose-rate (HDR) brachytherapy, a method for real-time localization of an HDR brachytherapy source was developed, which requires high spatial and temporal resolutions. MR-based localization of an HDR source serves two main aims. First, it enables real-time treatment verification by determination of the HDR source positions during treatment. Second, when using a dummy source, MR-based source localization provides an automatic detection of the source dwell positions after catheter insertion, allowing elimination of the catheter reconstruction procedure. Localization of the HDR source was conducted by simulation of the MR artifacts, followed by a phase correlation localization algorithm applied to the MR images and the simulated images, to determine the position of the HDR source in the MR images. To increase the temporal resolution of the MR acquisition, the spatial resolution was decreased, and a subpixel localization operation was introduced. Furthermore, parallel imaging (sensitivity encoding) was applied to further decrease the MR scan time. The localization method was validated by a comparison with CT, and the accuracy and precision were investigated. The results demonstrated that the described method could be used to determine the HDR source position with a high accuracy (0.4-0.6 mm) and a high precision (= 0.1 mm), at high temporal resolutions (0.15-1.2 s per slice). This would enable real-time treatment verification as well as an automatic detection of the source dwell positions.
机译：出于MR引导的高剂量率（HDR）近距离放射治疗的目的，开发了一种用于HDR近距离放射治疗来源的实时定位的方法，需要高空间和时间分辨率。基于MR的HDR源本地化有两个主要目标。首先，它通过确定治疗期间的HDR源位置来实现实时治疗验证。其次，当使用虚拟源时，基于MR的源定位在导管插入之后提供了自动检测源停留位置，允许消除导管重建过程。通过模拟MR伪像进行HDR源的定位，然后应用于MR图像和模拟图像的相位相关定期算法，以确定HDR图像中的HDR源的位置。为了增加MR采集的时间分辨率，空间分辨率下降，介绍了子像素定位操作。此外，应用并行成像（灵敏度编码）以进一步降低MR扫描时间。通过与CT的比较验证了定位方法，并研究了精度和精度。结果表明，所述方法可用于确定高精度（0.4-0.6mm）和高精度（＆ = 0.1 mm）的HDR源位置，在高时分辨率（每片0.15-1.2秒） 。这将使实时治疗验证能够自动检测源停留位置。

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