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首页> 外文期刊>Physics in medicine and biology. >Comparison of arterial input functions measured from ultra-fast dynamic contrast enhanced MRI and dynamic contrast enhanced computed tomography in prostate cancer patients
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Comparison of arterial input functions measured from ultra-fast dynamic contrast enhanced MRI and dynamic contrast enhanced computed tomography in prostate cancer patients

机译：从超快速动态对比度测量的动脉输入函数的比较增强的MRI和动态对比增强了前列腺癌患者的计算断层扫描

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摘要

The purpose of this study was to evaluate the accuracy of arterial input functions (AIFs) measured from dynamic contrast enhanced (DCE) MRI following a low dose of contrast media injection. The AIFs measured from DCE computed tomography (CT) were used as 'gold standard'. A total of twenty patients received CT and MRI scans on the same day. Patients received 120 ml Iohexol in DCE-CT and a low dose of (0.015 mM kg(-1)) of gadobenate dimeglumine in DCE-MRI. The AIFs were measured in the iliac artery and normalized to the CT and MRI contrast agent doses. To correct for different temporal resolution and sampling periods of CT and MRI, an empirical mathematical model (EMM) was used to fit the AIFs first. Then numerical AIFs (AIFCT and AIFMRI) were calculated based on fitting parameters. The AIFMRI was convolved with a 'contrast agent injection' function (AIFCON MRI) to correct for the difference between MRI and CT contrast agent injection times (similar to 1.5 s versus 30 s). The results show that the EMMs accurately fitted AIFs measured from CT and MRI. There was no significant difference (p 0.05) between the maximum peak amplitude of AIFs from CT (22.1 +/- 4.1 mM/dose) and MRI after convolution (22.3 +/- 5.2 mM/dose). The shapes of the AIFCT and AIFCON MRI were very similar. Our results demonstrated that AIFs can be accurately measured by MRI following low dose contrast agent injection.
机译：本研究的目的是评估从造影剂介质注射的低剂量后由动态对比增强（DCE）MRI测量的动脉输入功能（AIF）的准确性。从DCE计算机断层扫描（CT）测量的AIF被用作“金标准”。共有二十名患者在同一天接受CT和MRI扫描。患者在DCE-MRI中接受DCE-CT中的120ml碘碘和低剂量的（0.015mm kg（-1）甘油酸二聚戊酰胺。在髂动脉中测量AIF并标准化为CT和MRI造影剂剂量。为了校正CT和MRI的不同时间分辨率和采样周期，使用经验数学模型（EMM）首先适合AIF。然后基于拟合参数计算数值AIFS（AIFCT和AIFMRI）。将AIFMRI用“造影剂注入”功能（AIFCON MRI）卷曲，以校正MRI和CT造影剂注入时间（类似于1.5秒的30秒）之间的差异。结果表明，EMM精确地拟合来自CT和MRI测量的AIF。在卷积（22.3 +/- 4.1mm /剂量）和MRI的AIF的最大峰值幅度之间没有显着差异（P> 0.05）（22.3 +/- 5.2mm /剂量）。 AIFCT和AIFCON MRI的形状非常相似。我们的结果表明，低剂量造影剂注射后，通过MRI可以精确地测量AIF。

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