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首页> 外文期刊>Physics in medicine and biology. >Optimal transcostal high-intensity focused ultrasound with combined real-time 3D movement tracking and correction.
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Optimal transcostal high-intensity focused ultrasound with combined real-time 3D movement tracking and correction.

机译：最佳跨螺电高强度聚焦超声，具有组合实时3D运动跟踪和校正。

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摘要

Recent studies have demonstrated the feasibility of transcostal high intensity focused ultrasound (HIFU) treatment in liver. However, two factors limit thermal necrosis of the liver through the ribs: the energy deposition at focus is decreased by the respiratory movement of the liver and the energy deposition on the skin is increased by the presence of highly absorbing bone structures. Ex vivo ablations were conducted to validate the feasibility of a transcostal real-time 3D movement tracking and correction mode. Experiments were conducted through a chest phantom made of three human ribs immersed in water and were placed in front of a 300 element array working at 1 MHz. A binarized apodization law introduced recently in order to spare the rib cage during treatment has been extended here with real-time electronic steering of the beam. Thermal simulations have been conducted to determine the steering limits. In vivo 3D-movement detection was performed on pigs using an ultrasonic sequence. The maximum error on the transcostal motion detection was measured to be 0.09 +/- 0.097 mm on the anterior-posterior axis. Finally, a complete sequence was developed combining real-time 3D transcostal movement correction and spiral trajectory of the HIFU beam, allowing the system to treat larger areas with optimized efficiency. Lesions as large as 1 cm in diameter have been produced at focus in excised liver, whereas no necroses could be obtained with the same emitted power without correcting the movement of the tissue sample.
机译：最近的研究表明，肝脏高强度聚焦超声（HIFU）治疗在肝脏中的可行性。然而，两种因素通过肋骨限制肝脏的热坏死：通过肝脏的呼吸运动降低，通过高吸收的骨结构增加肝脏的呼吸运动，并且皮肤上的能量沉积增加。进行了exVivo消融以验证跨旋涡实时3D移动跟踪和校正模式的可行性。通过胸部模体进行实验，由三种人肋浸入水中，并置于在1MHz工作的300个元素阵列的前面。最近引入的二值化缩小法为了在处理期间备用肋骨，并且在这里延伸了梁的实时电子转向。已经进行了热仿真以确定转向限制。在使用超声序列对猪进行体内3D运动检测。在前后轴线上测量跨旋律运动检测的最大误差为0.09 +/- 0.097mm。最后，开发了一种完整的序列，组合HIFU光束的实时3D跨旋转运动校正和螺旋轨迹，允许系统以优化效率处理更大的区域。直径为1厘米的病变已经在聚焦的肝脏中产生，而不能在不校正组织样品的运动的情况下使用相同的发射功率获得任何拼混。

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