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首页> 外文期刊>Physics in medicine and biology. >Experimental exploration of a mixed helium/carbon beam for online treatment monitoring in carbon ion beam therapy
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Experimental exploration of a mixed helium/carbon beam for online treatment monitoring in carbon ion beam therapy

机译：碳离子束治疗中混合氦/碳束的实验探索

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摘要

Recently, it has been proposed that a mixed helium/carbon beam could be used for online monitoring in carbon ion beam therapy. Fully stripped, the two ion species exhibit approximately the same mass/charge ratio and hence could potentially be accelerated simultaneously in a synchrotron to the same energy per nucleon. At the same energy per nucleon, helium ions have about three times the range of carbon ions, which could allow for simultaneous use of the carbon ion beam for treatment and the helium ion beam for imaging. In this work, measurements and simulations of PMMA phantoms as well as anthropomorphic phantoms irradiated sequentially with a helium ion and a carbon ion beam at equal energy per nucleon are presented. The range of the primary helium ion beam and the fragment tail of the carbon ion beam exiting the phantoms were detected using a novel range telescope made of thin plastic scintillator sheets read out by a flat-panel CMOS sensor. A 10:1 carbon to helium mixing ratio is used, generating a helium signal well above the carbon fragment background while adding little to the dose delivered to the patient. The range modulation of a narrow air gap of 1 mm thickness in the PMMA phantom that affects less than a quarter of the particles in a pencil beam were detected, demonstrating the achievable relative sensitivity of the presented method. Using two anthropomorphic pelvis phantoms it is shown that small rotations of the phantom as well as simulated bowel gas movements cause detectable changes in the helium/carbon beam exiting the phantom. The future prospects and limitations of the helium/carbon mixing as well as its technical feasibility are discussed.
机译：近来，已经提出了混合的氦/碳束可用于在碳离子束疗法在线监测。完全剥离，这两个离子物种表现出大致相同的质量/电荷比，因此可以潜在地在同步加速器至每核子相同的能量同时加速。在每个核子相同的能量，氦离子具有碳离子，其可以允许用于治疗和用于成像的氦离子束同时使用碳离子束的3倍左右的范围内。在这项工作中，PMMA的测量和模拟体模以及拟人幻影用氦离子，并以每核子能量相等的碳离子束照射顺序地呈现。使用由薄的塑料闪烁体片的新颖范围望远镜检测主氦离子束和碳离子束离开体模的片段尾部的范围由平板CMOS传感器读出。 10：1的碳氦气混合比例使用，产生氦信号井的碳片段背景以上同时加入很少输送给患者的剂量。检测的在PMMA幻象影响小于在笔形射束的粒子的四分之一厚度为1mm的狭窄的空气间隙的范围调制，证明所提出的方法可达到的相对灵敏度。使用两个拟人骨盆幻影，示出了体模的小的旋转，以及模拟肠气的运动导致氦/碳光束离开幻象检测的变化。氦/碳混合以及其技术可行性的未来前景和局限性进行了讨论。

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