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首页> 外文期刊>Current opinion in allergy and clinical immunology >From innate to adaptive immune responses in contact hypersensitivity.
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From innate to adaptive immune responses in contact hypersensitivity.

机译：从先天性到适应性免疫反应中的超敏反应。

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摘要

PURPOSE OF REVIEW: To summarize recent findings that highlight the importance of the innate inflammatory immune responses in contact dermatitis and their role for the adaptive T-cell response to contact allergens. Implications for anti-inflammatory therapy based on recent reports are discussed. RECENT FINDINGS: Allergic contact dermatitis is studied widely in the mouse model. Recent work has identified an important role of innate pattern recognition receptors and innate immune cells in contact hypersensitivity. The role of skin dendritic cells has been studied with novel approaches for in-vivo depletion. New findings were made in the field of anti-inflammatory therapy either by uncovering new aspects of pathomechanisms or by the use of drugs that target different elements of the inflammatory cascade. SUMMARY: Inflammation is a pivotal element of allergic contact dermatitis. Studies in the mouse contact hypersensitivity model are beginning to shed light on the still largely unknown molecular mechanisms that enable contact allergens such as chemicals, metal ions and plant compounds to initiate the inflammatory innate immune response. This is a prerequisite for the adaptive immune response to occur. The recent progress in research points out the great potential of anti-inflammatory therapy covering a wide range of molecular targets.
机译：审查的目的：总结最近的发现，这些发现突出了先天性炎性免疫应答在接触性皮炎中的重要性及其在适应性T细胞应答接触性变应原中的作用。讨论了基于最新报道的抗炎治疗的意义。最近的发现：过敏性接触性皮炎在小鼠模型中得到了广泛的研究。最近的工作已经确定了先天性模式识别受体和先天性免疫细胞在接触性超敏反应中的重要作用。皮肤树突状细胞的作用已通过体内耗竭的新方法进行了研究。通过发现致病机制的新方面或通过使用针对炎症级联反应不同成分的药物，在抗炎治疗领域取得了新发现。摘要：炎症是过敏性接触性皮炎的关键因素。小鼠接触性超敏反应模型的研究开始阐明仍然十分未知的分子机制，该机制使接触性变应原（例如化学物质，金属离子和植物化合物）能够引发炎症性先天免疫应答。这是发生适应性免疫反应的前提。研究的最新进展指出了涵盖多种分子靶标的抗炎治疗的巨大潜力。

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