The role of tetrastarches for volume replacement in the perioperative setting.

James MF

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The role of tetrastarches for volume replacement in the perioperative setting.

机译：四淀粉在围手术期置换体积中的作用。

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PURPOSE OF REVIEW: Current opinion in perioperative fluid therapy suggests that the use of colloids to achieve haemodynamic optimization may result in improved clinical outcomes. This has focused interest on the colloid solutions, particularly on the newest of these, the tetrastarches. This review will address the advantages and disadvantages of the starch solutions with particular emphasis on the advantages offered by the tetrastarches, as these products, which have been widely used in Europe for a number of years, have recently been released in the United States. RECENT FINDINGS: The tetrastarches have a molar substitution of 0.4, compared with the older hetastarches that had a molar substitution of 0.7. This results in a lower in-vivo molecular weight leading to more rapid clearance of the starch particles and a reduced incidence of adverse effects such as coagulation disorders and skin itching. It is probable that the more rapidly degradable tetrastarch also decreases, or possibly eliminates, the risk of renal dysfunction that has been associated with some of the earlier starch products. SUMMARY: Tetrastarch represents a substantial advance in colloid therapy, offering good volume effectiveness with a very low risk of adverse effects.

机译：审查的目的：围手术期液体疗法的当前意见表明，使用胶体实现血液动力学优化可能会改善临床疗效。这引起了人们对胶体溶液的兴趣，尤其是其中最新的四淀粉。这篇综述将解决淀粉溶液的优缺点，特别强调四淀粉的优点，因为这些产品已在欧洲广泛使用多年，最近已在美国发布。最近的发现：四淀粉的摩尔取代度为0.4，而较老的七淀粉的摩尔取代度为0.7。这导致较低的体内分子量，导致淀粉颗粒的清除更快，并且降低了诸如凝结紊乱和皮肤瘙痒等不良反应的发生率。较快降解的四淀粉还可能减少或可能消除与某些早期淀粉产品有关的肾功能不全的风险。简介：四淀粉代表了胶体治疗的实质性进步，具有良好的容量效果，且不良反应风险极低。

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《Current opinion in anaesthesiology》 |2008年第5期|共5页
作者
James MF;
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正文语种 eng
中图分类外科手术学;
关键词
Volume; Starch; Role; Risk; Molar tooth; 淀粉; 角色; 危险;

机译：Volume;Starch;Role;Risk;Molar tooth;淀粉;角色;危险;

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1. The role of tetrastarches for volume replacement in the perioperative setting. [J] . James MF Current opinion in anaesthesiology . 2008,第5期

机译：四淀粉在围手术期置换体积中的作用。
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3. Perioperative volume replacement therapy for orthopic liver transplantation-observational, retrospective study [J] . Pavi??i?? ??ari?? Jadranka, Kocman Branislav, Gu??tin Denis, Medicina Fluminensis . 2018,第1期

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4. Perioperative Staff Planning Based on a 6-Week Volume Snapshot [C] . Di Li, Shengyong Wang, Chris Powers Annual Conference and Expo of the Institute of Industrial Engineers . 2014

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The role of tetrastarches for volume replacement in the perioperative setting.

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