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What investigation after an anaphylactic reaction during anaesthesia?

机译:麻醉期间出现过敏反应后应进行哪些检查?

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PURPOSE OF REVIEW: Anaphylactic reactions occurring during anaesthesia may be life threatening. Lethal issues may be involved in up to 3-10% of the cases. The allergological assessment (including biochemical tests and skin tests) is the key to the management of these reactions. The scope of this review is to focus on the allergological assessment required to prove the immune mechanism, to identify the culprit drug or substance and the cross-reactive molecules, especially for neuromuscular blocking agents, allowing preventive measures for future anaesthetic procedures. RECENT FINDINGS: To describe the allergological assessment (including biochemical tests and skin tests performed according to the current guidelines) in order to prove the immune mechanism as the responsibility of the culprit allergen. The most frequent and less frequent drugs involved are described. The different biological tools available are detailed. To ensure an accurate diagnosis, the interpretation of the allergological assessment should be linked to the description of the clinical events as their time onset following the injection/administration of the suspected drug(s)/substance. SUMMARY: To describe the different tools (biochemical tests and skin tests) available in order to prove the diagnosis of an anaphylactic reaction occurring during anaesthesia.
机译:审查目的:麻醉期间发生过敏反应可能危及生命。高达3-10%的案件可能涉及致命问题。过敏性评估(包括生化检查和皮肤检查)是管理这些反应的关键。这篇综述的重点是证明免疫机制所需的变应性评估,确定罪魁祸首的药物或物质以及交叉反应分子,特别是对于神经肌肉阻滞剂,从而为将来的麻醉程序提供预防措施。最近的研究结果:描述过敏学评估(包括根据当前指南进行的生化测试和皮肤测试),以证明免疫机制是罪魁祸首。描述了涉及的最频繁和不频繁的药物。详细介绍了可用的不同生物学工具。为确保准确诊断,应将变应性评估的解释与对临床事件的描述联系起来,因为这些事件是在注射/施用可疑药物/物质后开始的时间。摘要:描述可用的不同工具(生化测试和皮肤测试)以证明对麻醉期间发生的过敏反应的诊断。

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