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首页> 外文期刊>Current opinion in anaesthesiology >Conduction abnormalities and anaesthesia.
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Conduction abnormalities and anaesthesia.

机译：传导异常和麻醉。

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PURPOSE OF REVIEW: Accurate identification of patients at risk for ventricular arrhythmias is critical to prevent sudden cardiac death. The perioperative period is usually regarded as one of risk for potential triggering conditions. This review focuses on the anaesthesiologic risk of inherited arrhythmias whose aetiology is a mutation in genes encoding cardiac ion channels in the absence of structural heart abnormalities. RECENT FINDINGS: Genetic analysis identifies the genes whose expressions generate ion channel and regulating or anchoring subunits; electrophysiology can study the role of each ion current during cardiac fibrillation and develop many tests for risk. There is, however, a great heterogeneity of clinical phenotype and many histological studies detecting structural heart alterations despite negative noninvasive evaluations. SUMMARY: For some ion channel diseases, a therapy has been established; for others, the therapy and risk stratification are still matters of concern, and it is necessary to evaluate the new tools and tests available. For the highly lethal complication of these 'channellopathies', anaesthesia should proceed with caution in the light of the characteristics of each arrhythmia to prevent complications.
机译：审查目的：准确识别有室性心律失常危险的患者对于预防心源性猝死至关重要。围手术期通常被认为是潜在触发条件的风险之一。这篇综述着重于遗传性心律不齐的麻醉风险，其遗传学上的病因是在没有结构性心脏异常的情况下编码心脏离子通道的基因发生突变。最近的发现：遗传分析鉴定出其表达产生离子通道和调节或锚定亚基的基因。电生理学可以研究心脏颤动过程中每个离子电流的作用，并开发许多风险测试。然而，尽管阴性无创评估，临床表型的异质性很强，许多组织学研究检测心脏结构改变。摘要：对于某些离子通道疾病，已经建立了一种治疗方法。对于其他人而言，治疗和风险分层仍然是令人关注的问题，因此有必要评估可用的新工具和测试。对于这些“通道病”的高度致死性并发症，应根据每种心律不齐的特征谨慎进行麻醉，以防止并发症。

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