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首页> 外文期刊>Current opinion in biotechnology >Recent advances in mammalian synthetic biology-design of synthetic transgene control networks
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Recent advances in mammalian synthetic biology-design of synthetic transgene control networks

机译：哺乳动物合成生物学的最新进展-合成转基因控制网络的设计

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Capitalizing on an era of functional genomic research, systems biology offers a systematic quantitative analysis of existing biological systems thereby providing the molecular inventory of biological parts that are currently being used for rational synthesis and engineering of complex biological systems with novel and potentially useful functions-an emerging discipline known as synthetic biology. During the past decade synthetic biology has rapidly developed from simple control devices fine-tuning the activity of single genes and proteins to multi-gene/protein-based transcription and signaling networks providing new insight into global control and molecular reaction dynamics, thereby enabling the design of novel drug-synthesis pathways as well as genetic devices with unmatched biological functions. While pioneering synthetic devices have first been designed as test, toy, and teaser systems for use in prokaryotes and lower eukaryotes, first examples of a systematic assembly of synthetic gene networks in mammalian cells has sketched the full potential of synthetic biology: foster novel therapeutic opportunities in gene and cell-based therapies. Here we provide a concise overview on the latest advances in mammalian synthetic biology.
机译：借助功能基因组学研究的时代，系统生物学提供了对现有生物系统的系统定量分析，从而提供了目前用于合理合成和工程化具有新的和潜在有用功能的复杂生物系统的生物部分的分子清单。新兴学科被称为合成生物学。在过去的十年中，合成生物学已从简单的控制设备迅速发展，从微调单个基因和蛋白质的活性到基于多基因/蛋白质的转录和信号网络，为全面控制和分子反应动力学提供了新见识，从而使设计成为可能。新型药物合成途径以及具有无与伦比的生物学功能的遗传装置。最初将合成设备设计为用于原核生物和低等真核生物的测试，玩具和预告片系统，但哺乳动物细胞中合成基因网络系统组装的第一个例子却勾勒出了合成生物学的全部潜力：创造新的治疗机会在基于基因和细胞的疗法中。在这里，我们简要概述了哺乳动物合成生物学的最新进展。

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