Clostridia: the importance of their exceptional substrate and metabolite diversity for biofuel and biorefinery applications. (Special Issue: Energy biotechnology - Environmental biotechnology.)

Tracy B. P.; Jones S. W.; Fast A. G.; Indurthi D. C.; Papoutsakis E. T.

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Clostridia: the importance of their exceptional substrate and metabolite diversity for biofuel and biorefinery applications. (Special Issue: Energy biotechnology - Environmental biotechnology.)

机译：梭菌：其优异的底物和代谢产物多样性对于生物燃料和生物炼制应用的重要性。（特刊：能源生物技术-环境生物技术。）

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Clostridia are anaerobic Firmicutes producing a large array of metabolites by utilizing simple and complex carbohydrates, such as cellulose, as well as CO₂/H₂ or CO. Their exceptional substrate diversity is enhanced by their ability to produce a broad spectrum of chemicals that can be used as precursors to or directly as biofuels and industrial chemicals. Genetic and genomic tools are under intense development, and recent efforts to metabolically engineer clostridia demonstrate their potential for biofuel and biorefinery applications. Pathway engineering to combine established substrate-utilization programs, such as for cellulose, CO₂/H₂ or CO, with desirable metabolic programs could lead to modular design of strains suitable for many applications. Engineering complex phenotypes - aerotolerance, abolished sporulation, and tolerance to toxic chemicals - could lead to superior bioprocessing strains.

机译：梭状芽胞杆菌是厌氧菌，通过利用简单和复杂的碳水化合物（例如纤维素）以及CO _{2 / H _{2 或CO来产生大量代谢产物。它们产生广泛的化学物质的能力得到了增强，这些化学物质可以用作生物燃料和工业化学品的前体或直接用作生物燃料和工业化学品。遗传和基因组工具正在大力发展中，最近通过代谢工程改造梭状芽胞杆菌的努力证明了它们在生物燃料和生物精炼应用中的潜力。将已建立的底物利用程序（例如纤维素，CO _{2 / H _{2 或CO）与理想的代谢程序结合起来的途径工程，可能会导致适合于菌株的模块化设计许多应用。工程化复杂的表型-耐空气性，消除的孢子形成以及对有毒化学物质的耐受性-可能会导致产生出众的生物加工菌株。}}}}

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《Current opinion in biotechnology》 |2012年第3期|共18页
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Tracy B. P.; Jones S. W.; Fast A. G.; Indurthi D. C.; Papoutsakis E. T.;
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正文语种 eng
中图分类生物学实验与生物学技术;
关键词
anaerobes; bioenergy; biofuels; carbohydrates; carbon monoxide; cellulose; genomics; metabolism; metabolites; phenotypes; renewable energy; renewable resources; substrates; toxic substances; Clostridium; Firmicutes; Clostridiaceae; Clostridiales; Clostridia; Firmicutes; Bacteria; prokaryotes; anaerobic micro-organisms; anaerobic microorganisms; bacterium; poisons; saccharides;

机译：厌氧菌;生物能源;生物燃料;碳水化合物;一氧化碳;纤维素;基因组学;新陈代谢;代谢产物;表型;可再生能源;可再生资源;底物;有毒物质;梭状芽孢杆菌;拟杆菌;克氏菌;克氏梭菌;小球藻;费氏菌-生物;厌氧微生物;细菌;毒物;糖类;

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1. Clostridia: the importance of their exceptional substrate and metabolite diversity for biofuel and biorefinery applications. (Special Issue: Energy biotechnology - Environmental biotechnology.) [J] . Tracy B. P., Jones S. W., Fast A. G., Current opinion in biotechnology . 2012,第3期

机译：梭菌：其优异的底物和代谢产物多样性对于生物燃料和生物炼制应用的重要性。（特刊：能源生物技术-环境生物技术。）
2. Algae biofuels: versatility for the future of bioenergy. (Special Issue: Energy biotechnology - Environmental biotechnology.) [J] . Jones C. S., Mayfield S. P. Current opinion in biotechnology . 2012,第3期

机译：藻类生物燃料：未来生物能源的多功能性。（特刊：能源生物技术-环境生物技术。）
3. Exploration of natural biomass utilization systems (NBUS) for advanced biofuel - from systems biology to synthetic design. (Special Issue: Energy biotechnology - environmental biotechnology.) [J] . Xie S. X., Syrenne R., Sun S., Current opinion in biotechnology . 2014,第Null期

机译：探索用于高级生物燃料的天然生物利用系统（NBUS）-从系统生物学到合成设计。（特刊：能源生物技术-环境生物技术。）
4. Bio-inspired synthesis of functional materials on substrates for environmental and energy applications. [D] . Meng, Xinghua. 2016

机译：以生物为灵感在基材上合成功能材料，用于环境和能源应用。
5. Correction: Hunt R.W. et al. Electromagnetic Biostimulation of Living Cultures for Biotechnology Biofuel and Bioenergy Applications. Int. J. Mol. Sci. 2009 10 4515–4558 [O] . Ryan W. Hunt, Andrey Zavalin, Ashish Bhatnagar, 2009

机译：校正：HuntR.W.等。用于生物技术生物燃料和生物能源应用的活文化的电磁生物刺激。诠释J.摩尔科学2009104515–4558
6. Special issue: Application of biotechnology for biofuels: transforming biomass to biofuels [O] . Ashutosh Mittal, Stephen R. Decker 2013

机译：特刊：生物技术在生物燃料中的应用：将生物质转化为生物燃料

Clostridia: the importance of their exceptional substrate and metabolite diversity for biofuel and biorefinery applications. (Special Issue: Energy biotechnology - Environmental biotechnology.)

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