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首页> 外文期刊>Current oncology reports. >Diagnosis and treatment of acute promyelocytic leukemia.
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Diagnosis and treatment of acute promyelocytic leukemia.

机译：急性早幼粒细胞白血病的诊断和治疗。

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摘要

Acute promyelocytic leukemia (APL), characterized by a translocation between the promyelocytic leukemia gene (PML) on chromosome 15 and the retinoic acid receptor-alpha (RARalpha) gene on chromosome 17, has become a model for targeted treatment of cancer. Advances in our understanding of the fundamental biology of this disease have led to the development of tools for diagnosis, monitoring of minimal residual disease, and detection of early relapse. Differentiation therapy with all-trans retinoic acid in combination with chemotherapy has significantly improved survival in patients with APL. Moreover, arsenic trioxide, which induces differentiation and apoptosis of APL cells, has become standard treatment for relapsed disease, and its role in the treatment of newly diagnosed APL is under active investigation. The lessons learned from APL have broad applications to other forms of leukemia and to cancer in general, whereby molecularly targeted therapy is directed to specifically defined subgroups.
机译：急性早幼粒细胞白血病（APL）的特征是在15号染色体上的早幼粒细胞白血病基因（PML）和17号染色​​体上的视黄酸受体-α（RARalpha）基因之间易位，已成为靶向治疗癌症的模型。我们对这种疾病的基本生物学的理解的进步导致了诊断工具，最小残留疾病的监测以及早期复发的检测工具的开发。全反式维甲酸联合化学疗法的分化疗法显着提高了APL患者的生存率。此外，诱导APL细胞分化和凋亡的三氧化二砷已成为复发性疾病的标准治疗方法，其在治疗新诊断的APL中的作用正在积极研究中。从APL汲取的经验教训已广泛应用于其他形式的白血病和一般而言的癌症，因此分子靶向治疗针对的是明确定义的亚组。

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