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What is the role of chemotherapy in endometrial cancer?

机译:化疗在子宫内膜癌中起什么作用?

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Adjuvant pelvic radiotherapy has the potential to eradicate micrometastases within the irradiated field but has not resulted in survival improvements in randomized studies. This illustrates the need for systemic therapy. Chemotherapy, mainly with anthracyclines, platinum compounds, and taxanes, renders high response rates although this unfortunately translates in only modest improvements in progression-free and overall survival. Better systemic treatments need to be developed. Investigations of the molecular mechanisms of endometrial cancer have identified possible targets for therapy. In advanced endometrial cancer one study shows that chemotherapy is better than whole abdominal radiotherapy, while in the adjuvant situation the combination of chemotherapy and radiotherapy appears promising.
机译:骨盆辅助放疗有可能根除被照射野内的微小转移,但在随机研究中并未导致生存改善。这说明需要全身治疗。主要用蒽环类,铂类化合物和紫杉烷类化合物进行的化学疗法可产生较高的反应率,尽管不幸的是,这仅能使无进展生存期和总体生存率有所改善。需要开发更好的全身治疗方法。对子宫内膜癌分子机制的研究已经确定了可能的治疗靶标。在晚期子宫内膜癌中,一项研究表明化学疗法优于全腹放射疗法,而在辅助情况下,化学疗法和放射疗法的结合似乎很有希望。

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