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A computational study of droplet-based bioprinting: Effects of viscoelasticity

机译：基于液滴的生物化学术的计算研究：粘弹性的影响

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摘要

Despite significant progress, cell viability continues to be a central issue in droplet-based bioprinting applications. Common bioinks exhibit viscoelastic behavior owing to the presence of long-chain molecules in their mixture. We computationally study effects of viscoelasticity of bioinks on cell viability during deposition of cell-loaded droplets on a substrate using a compound droplet model. The inner droplet, which represents the cell, and the encapsulating droplet are modeled as viscoelastic liquids with different material properties, while the ambient fluid is Newtonian. The model proposed by Takamatsu and Rubinsky ["Viability of deformed cells," Cryobiology 39(3), 243-251 (1999)] is used to relate cell deformation to cell viability. We demonstrate that adding viscoelasticity to the encapsulating droplet fluid can significantly enhance the cell viability, suggesting that viscoelastic properties of bioinks can be tailored to achieve high cell viability in droplet-based bioprinting systems. The effects of the cell viscoelasticity are also examined, and it is shown that the Newtonian cell models may significantly overpredict the cell viability. Published under license by AIP Publishing.
机译：尽管取得了重大进展，但细胞活力仍然是基于液滴的生物监测应用中的核心问题。由于它们的混合物中的长链分子存在，常见的生物链表现出粘弹性行为。我们使用复合液滴模型计算在衬底上沉积细胞负载液滴期间对细胞活性的粘弹性的效果。表示细胞的内液滴和封装液滴被建模为具有不同材料特性的粘弹性液体，而环境流体是牛顿的。 Takamatsu和Rubinsky提出的模型[“变形细胞的活力”，Crybiology 39（3），243-251（1999）]用于将细胞变形与细胞活力相关。我们证明向包封液滴添加粘弹性可以显着提高细胞活力，表明可以根据基于液滴的生物印刷系统中实现高细胞活力来定制生物链的粘弹性性能。还检查了细胞粘弹性的影响，结果表明，牛顿细胞模型可能显着过度估计细胞活力。通过AIP发布在许可证下发布。

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  • 来源
    《Physics of fluids》 |2019年第8期|共13页
  • 作者

    Nooranidoost M.; Izbassarov D.; Tasoglu S.; Muradoglu M.;

  • 作者单位

    Koc Univ Dept Mech Engn TR-34450 Istanbul Turkey;

    Koc Univ Dept Mech Engn TR-34450 Istanbul Turkey;

    Univ Connecticut Connecticut Inst Brain &

    Cognit Sci Inst Collaborat Hlth Intervent &

    Policy Dept Biomed Engn Inst Mat Sci Dept Mech Engn Storrs CT 06269 USA;

    Koc Univ Dept Mech Engn TR-34450 Istanbul Turkey;

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  • 正文语种 eng
  • 中图分类 流体力学;
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