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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Transport of prefolded proteins in bacteria: an overview on twin arginine transport pathway and its role in pathogenesis
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Transport of prefolded proteins in bacteria: an overview on twin arginine transport pathway and its role in pathogenesis

机译：细菌中预折叠蛋白的运输：双精氨酸运输途径及其在发病机理中的作用概述

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摘要

Soon after synthesis, proteins are transported to their respective destinations to perform various cellular activities needed for the survival of the cell. Protein trafficking is a complex process. In prokaryotes, 16 different mechanisms are involved in transporting the proteins to their respective destinations. Interestingly, except one, the rest of them transport unfolded proteins. A number of proteins acquire folded conformation before targeting/transporting across membranes. Such prefolded proteins are transported through a novel pathway, known as twin arginine transport (Tat) pathway. The Tat pathway is found in both Gram-positive as well as Gram-negative bacteria and plays a key role in various cellular activities including pathogenesis. The review provides a comprehensive picture of the mechanism of the Tat pathway and describes its role in pathogenesis.
机译：合成后不久，蛋白质被转运到它们各自的目的地，以执行细胞存活所需的各种细胞活动。蛋白质运输是一个复杂的过程。在原核生物中，有16种不同的机制参与将蛋白质运输到它们各自的目的地。有趣的是，除一种外，其余的都运输未折叠的蛋白质。许多蛋白质在靶向/跨膜转运之前获得折叠的构象。此类预折叠的蛋白质通过一种称为双精氨酸转运（Tat）的新型途径转运。 Tat途径在革兰氏阳性细菌和革兰氏阴性细菌中均发现，并且在包括发病机理在内的各种细胞活动中起关键作用。该综述提供了Tat途径机制的全面描述，并描述了其在发病机理中的作用。

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