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首页> 外文期刊>Current opinion in anaesthesiology >Systemic lidocaine in surgical procedures: Effects beyond sodium channel blockade
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Systemic lidocaine in surgical procedures: Effects beyond sodium channel blockade

机译：外科手术中的全身性利多卡因：钠通道阻滞以外的作用

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Purpose of Review: This review presents current data on the systemic administration of lidocaine. The focus is on studies in the perioperative setting. In addition, there is a brief look at experimental data on the effect of lidocaine at the molecular level. Recent Findings: Several recent randomized prospective studies have reported lower postoperative pain values and less opioid administration in lidocaine groups in comparison with control groups receiving NaCl. However, there are conflicting data particularly in relation to patients undergoing nonabdominal surgery and on effects on postoperative resumption of bowel motility and hospital discharge times. Unfortunately, hardly any studies have investigated the effects of systemic lidocaine in comparison with epidural anesthesia. At the molecular level, a number of receptors and signal transduction cascades have been identified. Summary: Positive effects on postoperative pain, as well as on bowel motility and hospital discharge time, have regularly been observed. However, contradictory findings have also been published. As almost all of the studies only include very small patient numbers, large multicenter investigations are needed.
机译：综述的目的：本综述介绍了利多卡因全身给药的最新数据。重点是围手术期的研究。此外，简要介绍了利多卡因在分子水平上的作用的实验数据。最新发现：与接受NaCl的对照组相比，利多卡因组的近期术后前瞻性研究报道了较低的术后疼痛值和较少的阿片类药物给药。但是，尤其是关于接受非腹部手术的患者以及对术后肠蠕动恢复和出院时间的影响，数据存在矛盾。不幸的是，与硬膜外麻醉相比，几乎没有任何研究研究全身利多卡因的作用。在分子水平上，已经鉴定出许多受体和信号转导级联。摘要：定期观察到对术后疼痛，肠蠕动和出院时间有积极影响。但是，矛盾的发现也已经发表。由于几乎所有研究仅包括很少的患者人数，因此需要进行大型的多中心研究。

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