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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Artemisinin-based combination with curcumin adds a new dimension to malaria therapy
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Artemisinin-based combination with curcumin adds a new dimension to malaria therapy

机译：青蒿素与姜黄素的组合为疟疾治疗增加了新领域

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摘要

Malaria afflicts 300 million people worldwide, with over a million deaths every year. With no immediate prospect of a vaccine against the disease, drugs are the only choice to treat it. Unfortunately, the parasite has become resistant to most antimalarials, restricting the option to use artemisinins (ARTs) for effective cure. With the use of ARTs as the front-line antimalarials, reports are already available on the possible resistance development to these drugs as well. Therefore, it has become necessary to use ART-based combination therapies to delay emergence of resistance. It is also necessary to discover new pharmacophores to eventually replace ART. Studies in our laboratory have shown that curcumin not only synergizes with ART as an antimalarial to kill the parasite, but is also uniquely able to prime the immune system to protect against parasite recrudescence in the animal model. The results indicate a potential for the use of ART curcumin combination against recrudescence/relapse in falciparum and vivax malaria. In addition, studies have also suggested the use of curcumin as an adjunct therapy against cerebral malaria. In this review we have attempted to highlight these aspects as well as the studies directed to discover new pharmacophores as potential replacements for ART.
机译：疟疾困扰着全世界3亿人，每年有超过100万人死亡。由于目前尚无针对该疾病的疫苗的前景，因此药物是治疗该疾病的唯一选择。不幸的是，该寄生虫已对大多数抗疟药产生抗药性，从而限制了使用青蒿素（ART）进行有效治愈的选择。随着抗逆转录病毒疗法作为一线抗疟药的使用，关于这些药物可能产生耐药性的报道也已经存在。因此，有必要使用基于ART的联合疗法来延迟耐药性的出现。也有必要发现新的药效基团以最终替代ART。我们实验室的研究表明，姜黄素不仅可以与抗疟疾抗病毒药ART协同作用，而且可以独特地引发免疫系统，从而防止动物模型中的寄生虫复发。结果表明使用ART姜黄素联合治疗恶性疟和间日疟的复发/复发的潜力。此外，研究还建议使用姜黄素作为抗脑疟的辅助疗法。在这篇综述中，我们试图强调这些方面以及针对发现新药效基团作为ART潜在替代品的研究。

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