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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Small is the new big - interplay of miRNAs in cancer
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Small is the new big - interplay of miRNAs in cancer

机译:从小到大-癌症中miRNA的相互作用

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摘要

MicroRNAs (miRNAs) are small non-coding regulatory RNAs that post-transcriptionally regulate gene expression. About 1500 miRNAs have been discovered in humans and these can target and regulate up to 60% of coding genes. MicroRNAs play a key role in all cellular functions and are implicated in most diseases, including cancer. Deregulation of microRNA expression can affect various metabolic and signalling pathways and results in cancer development and progression. This review provides a comprehensive view of various cancer types and their associated microRNAs.
机译:MicroRNA(miRNA)是小的非编码调控RNA,可在转录后调控基因表达。在人类中已发现约1500个miRNA,它们可以靶向并调节多达60%的编码基因。 MicroRNA在所有细胞功能中都起着关键作用,并与包括癌症在内的大多数疾病有关。 microRNA表达的失调会影响各种代谢和信号传导途径,并导致癌症的发展和进展。这篇综述提供了各种癌症类型及其相关的microRNA的全面视图。

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