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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Does the natural resistance associated macrophage protein (Nramp) gene confer resistance/susceptibility in bovines against mycobacterial infection?
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Does the natural resistance associated macrophage protein (Nramp) gene confer resistance/susceptibility in bovines against mycobacterial infection?

机译：天然抗性相关的巨噬细胞蛋白（Nramp）基因是否赋予牛抗分枝杆菌感染的抗性/敏感性？

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摘要

The progression of mycobacterial infection in mice is known to be controlled by the 'Bcg' locus which harbours the Natural resistance associated macrophage protein (Nramp) gene. In mice, specific point mutations at this locus have been shown to segregate with resistance and susceptibility to tuberculosis (TB). In order to verify whether a similar situation exists in the bovine genome, Nramp genomic sequences from 10 TB-infected and 10 uninfected cattle were analysed by polymerase chain reaction-restriction fragment length polymorphism. AluI and TaqI were the best restriction endonucleases for determining haplotypes; they detected 3 and 2 allelic patterns, respectively. The polymorphism at the Nramp locus was small and there were no significant differences in the pattern and frequency of the alleles between the infected and non-infected groups. It is concluded that it is unlikely that Nramp alone is responsible for conferring resistance against TB in cattle.
机译：已知小鼠中分枝杆菌感染的进展受“ Bcg”基因座的控制，该基因座具有与自然抗性相关的巨噬细胞蛋白（Nramp）基因。在小鼠中，该位点的特定点突变已显示与耐药性和结核病（TB）易感性分离。为了验证牛基因组中是否存在类似情况，通过聚合酶链反应-限制性片段长度多态性分析了来自10 TB感染的牛和10个未感染的牛的Nramp基因组序列。 AluI和TaqI是确定单倍型的最佳限制性核酸内切酶。他们分别检测了3和2个等位基因模式。 Nramp基因座的多态性很小，在感染和未感染组之间等位基因的模式和频率没有显着差异。结论是，单独的Nramp不可能赋予牛抗结核病的责任。

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