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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Tumour oxygenation measurements by ~(19)F magnetic resonance imaging of perfluorocarbons
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Tumour oxygenation measurements by ~(19)F magnetic resonance imaging of perfluorocarbons

机译：通过〜（19）F磁共振成像对全氟化碳进行肿瘤氧合测量

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摘要

Solid tumours are well known to be heterogeneous and contain a significant fraction of hypoxic cells, which are protected against the effects of radiotherapy. A non-invasive method for measuring tissue oxygenation would therefore be useful. The ~(19)F magnetic resonance signals from perfluorocarbons are sensitive to oxygen concentration. We have used this property to measure tumor oxygenation of the GH3 prolactinoma, RIF-1 fibrosarcoma and SaF sarcoma in mice by fluorine magnetic resonance imaging (MRI) of intravenously injected perfluorocarbons which are taken up by macrophages in the tumor. We have also studied the injection of perfluorocarbons directly into the tumous, which allows less of the tumor to be studied but has a higher success rate and gives values more consistent with Eppendorf polarographic electrode measurements.
机译：众所周知，实体瘤是异质性的，并且含有很大一部分缺氧细胞，这些细胞被保护免受放射疗法的影响。因此，用于测量组织氧合的非侵入性方法将是有用的。来自全氟化碳的〜（19）F磁共振信号对氧浓度敏感。我们已经通过静脉内注射全氟化碳的氟磁共振成像（MRI）来测量小鼠体内GH3催乳素瘤，RIF-1纤维肉瘤和SaF肉瘤的肿瘤氧合作用，所述全氟碳被肿瘤中的巨噬细胞吸收。我们还研究了将全氟化碳直接注射到肿瘤中的方法，这使得研究的肿瘤更少，但成功率更高，并且给出的值与Eppendorf极谱电极测量结果更加一致。

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