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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >LITOMOSOIDES CARINII AND ACANTHOCHEILONEMA VITEAE IN RODENTS - THE INFLUENCE OF NONSPECIFIC IMMUNOSUPPRESSION ON ESTABLISHMENT OF FILARIAL INFECTION
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LITOMOSOIDES CARINII AND ACANTHOCHEILONEMA VITEAE IN RODENTS - THE INFLUENCE OF NONSPECIFIC IMMUNOSUPPRESSION ON ESTABLISHMENT OF FILARIAL INFECTION

机译：啮齿类动物中的脂寡糖Carinii和Vantae-非特异性免疫抑制对建立丝状感染的影响

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Prolonged incubation period and poor establishment rate of adult filarial parasites in experimental host have jeopardized much of laboratory investigational activities, Study was therefore planned with the objectives of shortening the prolonged incubation period of filarial infection and enhancing the establishment rate of macrofilariids with high peripheral microfilaraemia in host, It was observed that cortisone treatment in rodents at 10 mg/kg, subcutaneously from day -7 to day +7 in two courses at week's interval, not only reduced the prepatent period of both Litomosoides carinii and Acanthocheilonema vitae infections by 10 days but also increased the adult worm recovery to a significant extent, Microfilarial level remained higher in cortisone-treated animals throughout the observation period, It was also interesting to note that length of adult male and female filariids (A, viteae) recovered from treated animals was significantly more in comparison to controls, The carbohydrate metabolism of recovered parasites from cortisone-treated hosts remained unaltered and thereby, remained suitable for various experimental purposes. [References: 26]
机译：在实验宿主中延长潜伏期和成人丝虫寄生物的建立率很低，危害了许多实验室研究活动，因此计划进行研究，目的是缩短延长的丝虫感染的潜伏期并提高具有高外周微丝血症的巨丝虫的发生率。宿主，观察到在隔周的两个疗程中从第-7天到第+7天皮下注射10 mg / kg的可的松鼠，每星期间隔两次，不仅减少了Cartoii Litomosoides和Acanthocheilonema vitamin感染的发生期10天，而且还大大提高了成虫的蠕虫恢复率，在整个观察期内，可的松治疗的动物的微丝水平仍保持较高水平。有趣的是，从治疗的动物中回收的成年雄性和雌性丝虫（A，卵黄素）的长度显着增加。与对照相比，碳水化合物含量更高从可的松治疗的宿主中回收的寄生虫的代谢保持不变，因此，仍适用于各种实验目的。 [参考：26]

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