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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >ISOLATION AND CHARACTERIZATION OF AN INSERTION ELEMENT-LIKE REPETITIVE SEQUENCE SPECIFIC FOR MYCOBACTERIUM TUBERCULOSIS COMPLEX
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ISOLATION AND CHARACTERIZATION OF AN INSERTION ELEMENT-LIKE REPETITIVE SEQUENCE SPECIFIC FOR MYCOBACTERIUM TUBERCULOSIS COMPLEX

机译：结核分枝杆菌复杂的插入元素样重复序列的分离和表征

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摘要

We report the characterization of an insertion-like repetitive sequence containing the clone of Mycobacterium tuberculosis. This repetitive sequence contains seven inverted repeats. Restriction fragment length polymorphism studies using this probe have shown that it is not a highly polymorphic probe but rather shows conservative fingerprint pattern. Out of the 150 strains tested, only three showed different fingerprint patterns. It has several direct and inverted repeats. Hormology studies of the putative protein coding region show that this repeat element might code for a metalloproteinase of M. tuberculosis. Homology studies also implicate this repeat element to be from a very essential region of the M. tuberculosis genome participating in recombination. This repeat has been found to be an ideal target for polymerase chain reaction to detect M. tuberculosis. [References: 17]
机译：我们报告了包含结核分枝杆菌克隆的插入样重复序列的表征。该重复序列包含七个反向重复。使用该探针的限制性片段长度多态性研究表明，它不是高度多态的探针，而是显示出保守的指纹图谱。在测试的150个菌株中，只有三个显示出不同的指纹模式。它具有多个直接和反向重复。对假定的蛋白质编码区的钟表研究表明，该重复元件可能编码结核分枝杆菌的金属蛋白酶。同源性研究也暗示该重复元件来自参与重组的结核分枝杆菌基因组的非常重要的区域。已经发现该重复是用于检测结核分枝杆菌的聚合酶链反应的理想靶标。 [参考：17]

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