DNA therapy for asthma.

Kline JN

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DNA therapy for asthma.

机译：DNA治疗哮喘。

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Asthma therapy, like other therapies, has been moving towards a molecular basis for several years. This year, there have been several preclinical studies published which utilize attributes or facets of DNA to address asthma therapeutics. These include antisense oligonucleotides (against the nuclear transcription factor GATA-3 and the mast cell chemotactic agent, stem cell factor), gene transfer (of interleukin-18, both by plasmid and viral vectors), and CpG oligodeoxynucleotides (which suppress Th2 and stimulate Th1 responses). No clinical experience has yet been reported for any of these areas of research in asthma, but clinical trials are ongoing utilizing CpG oligonucleotides.

机译：与其他疗法一样，哮喘疗法已在分子基础上发展了几年。今年，已经发表了几项临床前研究，这些研究利用DNA的属性或方面来解决哮喘的治疗方法。这些包括反义寡核苷酸（针对核转录因子GATA-3和肥大细胞趋化剂，干细胞因子），基因转移（白介素18的质粒和病毒载体）以及CpG寡脱氧核苷酸（抑制Th2并刺激Th1响应）。对于哮喘的任何这些研究领域，尚无临床经验的报道，但正在利用CpG寡核苷酸进行临床试验。

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《Current opinion in allergy and clinical immunology》 |2002年第1期|共5页
作者
Kline JN;
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正文语种 eng
中图分类医学免疫学;
关键词
Asthma; Gene Therapy; Interleukin-18; 哮喘; 基因疗法; 白细胞介素18;

机译：Asthma;Gene Therapy;Interleukin-18;哮喘;基因疗法;白细胞介素18;

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1. DNA therapy for asthma. [J] . Kline JN Current opinion in allergy and clinical immunology . 2002,第1期

机译：DNA治疗哮喘。
2. Proof of concept study to evaluate step-down therapy with inhaled corticosteroid alone or additive therapy on surrogate inflammatory markers in asthma. [J] . McKinlay L, Williamson PA, Short PM, British Journal of Clinical Pharmacology . 2011,第1期

机译：评估仅用吸入皮质类固醇的降压疗法或哮喘替代性炎症标志物的加成疗法的概念研究证明。
3. Benefits of fixed-dose combination therapy with inhaled corticosteroids and long-acting bronchodilators as initial maintenance therapy in the management of asthma. [J] . Seale JP, Jenkins C, Wood Baker R, Respirology : . 2009,第2期

机译：吸入皮质类固醇和长效支气管扩张剂的固定剂量联合治疗在哮喘管理中作为初始维持治疗的益处。
4. Pathogenetic therapeutic decision of immunotherapy in the patients with infection-dependent bronchial asthma. [C] . Kostina E.M. World Congress on Immunopathology Respiratory Allergy . 2012

机译：感染依赖性支气管哮喘患者免疫疗法的致病治疗决策。
5. Immunotherapeutic role of allergen-DNA conjugates in allergic asthma. [D] . Santeliz Casavilca, Joanna Veruschka. 2003

机译：过敏原-DNA缀合物在过敏性哮喘中的免疫治疗作用。
6. Letter: Disodium cromoglycate and DNA-ase in treatment of bronchial asthma. [O] . A A Demin 1976

机译：信函：葡萄糖酸二钠和DNA酶治疗支气管哮喘。
7. Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma. [O] . Gunawardhana, Lakshitha, Gibson, Peter G., Simpson, Jodie L., 2014

机译：外周血单核细胞中的特征性DNA甲基化谱与哮喘的炎症表型有关。
8. DNA Base Excision Repair (BER) and Cancer Gene Therapy: Use of the Human N-mythlpurien DNA Glycosylase (MPG) to Sensitize Breast Cancer Cells to Low Dose Chemotherapy [R] . Harvey, T. , Kelly, M. R. 2003

机译：DNa碱基切除修复（BER）和癌症基因治疗：使用人类N-mythlpurien DNa糖基化酶（mpG）使乳腺癌细胞对低剂量化疗敏感

DNA therapy for asthma.

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