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首页> 外文期刊>Current opinion in allergy and clinical immunology >Highlights in nonhymenoptera anaphylaxis.
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Highlights in nonhymenoptera anaphylaxis.

机译：非膜翅目过敏症的重点。

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摘要

PURPOSE OF REVIEW: The purpose of this review is to summarize new interesting findings in both research and clinical practice of nonhymenoptera anaphylaxis with particular emphasis on food and drug allergy. RECENT FINDINGS: Recent findings include some aspects of crossreactivity among betalactams, nonsteroidal anti-inflammatory drugs with special attention to an immunogenic metabolite of diclofenac and the mode of diclofenac-induced basophil degranulation. Also, new insights into the sometimes atypical anaphylaxis-like reactions after administration of monoclonal antibodies and the immunologic response to these molecules will be discussed, as well as the role of low-dose pholcodine exposure on the development of sensitization to neuromuscular blocking agents. In food-related anaphylaxis, a significant increase of incidents has been observed over the last few years, especially among children of less than 5 years of age. Unfortunately, the severity of subsequent reactions cannot be predicted from the reaction history. Tree nuts and peanuts are the most important elicitors of fatal food-induced anaphylaxis. SUMMARY: In food-related anaphylaxis, prospectively evaluated marker allergens that are indicative of a potential anaphylactic reaction are still lacking. The drug groups covered in this review are of special interest either due to their prominent role as allergens or due to new findings.
机译：审查的目的：这项审查的目的是总结非膜翅目过敏的研究和临床实践中的新发现，特别是对食物和药物过敏的研究。最近的发现：最近的发现包括β-内酰胺类，非甾体类抗炎药之间的交叉反应性的某些方面，特别注意双氯芬酸的免疫原性代谢产物和双氯芬酸诱导的嗜碱性粒细胞脱粒的模式。此外，还将讨论在施用单克隆抗体后对有时非典型过敏反应样反应以及对这些分子的免疫反应的新见解，以及低剂量羟可可碱暴露对神经肌肉阻滞剂致敏作用的作用。在与食物有关的过敏反应中，最近几年发生的事件明显增多，尤其是在5岁以下的儿童中。不幸的是，后续反应的严重性不能根据反应历史来预测。坚果和花生是致命的食物诱发过敏反应的最重要诱因。摘要：在与食物有关的过敏反应中，仍缺乏前瞻性评估的指示潜在过敏反应的标记物过敏原。由于它们作为过敏原的突出作用或由于新发现，本综述中涉及的药物组引起了特别关注。

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