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Linear, no threshold response at low doses of ionizing radiation: ideology, prejudice and science

机译:线性,低剂量电离辐射无阈值响应:意识形态,偏见和科学

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摘要

The linear, no threshold (LNT) response model assumes that there is no threshold dose for the radiation-induced genetic effects (heritable mutations and cancer), and it forms the current basis for radiation protection standards for radiation workers and the general public. The LNT model is, however, based more on ideology than valid radiobiological data. Further, phenomena such as 'radiation hormesis', 'radioadaptive response', 'bystander effects' and 'genomic instability' are now demonstrated to be radioprotective and beneficial. More importantly, the 'differential gene expression' reveals that qualitatively different proteins are induced by low and high doses. This finding negates the LNT model which assumes that qualitatively similar proteins are formed at all doses. Thus, all available scientific data challenge the LNT hypothesis.
机译:线性无阈值(LNT)响应模型假定没有针对辐射诱发的遗传效应(可遗传突变和癌症)的阈值剂量,并且它构成了辐射工作者和一般公众的辐射防护标准的当前基础。然而,LNT模型更多是基于意识形态,而不是有效的放射生物学数据。而且,诸如“辐射兴奋”,“放射适应性反应”,“旁观者效应”和“基因组不稳定性”等现象现已证明具有放射防护性和有益性。更重要的是,“差异基因表达”揭示了高剂量和低剂量诱导的蛋白质性质上的差异。这一发现否定了LNT模型,该模型假定在所有剂量下都形成了定性相似的蛋白质。因此,所有可用的科学数据都对LNT假设提出了挑战。

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