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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Dynamic magnetic resonance imaging in assessment of tumour blood flow and oxygenation
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Dynamic magnetic resonance imaging in assessment of tumour blood flow and oxygenation

机译：动态磁共振成像评估肿瘤血流和氧合

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摘要

Tumour blood flow and oxygenation are among the important determinants of various non-surgical forms of cancer treatments. To improve the treatment efficacy, several agents that modify blood flow in tumours are currently under intensive investigation. Thus a noninvasive approach to study the effects of these agents on tumor blood flow and oxygenation would be of great use. Recent advances in magnetic resonance imaging (MRI) methodology make it possible to monitor dynamically the changes in tissue blood flow and oxygenation with a better spatial and temporal resolution. In this context, the applications of dynamic Gd-DTPA and BOLD contrast enhanced MRI to monitor the changes in tumor blood flow and oxygenation are reviewed in the present article. The usefulness of such measurements in tumor radiotherapy is illustrated. By studies on the effects induced by diltiazem, a calcium channel blocker, on a murine tumor model.
机译：肿瘤的血流量和氧合是各种非手术形式癌症治疗的重要决定因素。为了提高治疗效果，目前正在深入研究几种改变肿瘤血流的药物。因此，研究这些药物对肿瘤血流和氧合作用的非侵入性方法将很有用。磁共振成像（MRI）方法的最新进展使得可以动态监视组织血流和氧合作用的变化具有更好的时空分辨率。在这种情况下，本文综述了动态Gd-DTPA和BOLD对比增强MRI在监测肿瘤血流和氧合变化中的应用。说明了这种测量在肿瘤放疗中的有用性。通过研究地尔硫卓（一种钙通道阻滞剂）对鼠肿瘤模型的诱导作用。

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