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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Glycated hemoglobin [Review]
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Glycated hemoglobin [Review]

机译：糖化血红蛋白[综述]

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Glycated hemoglobin (GHb) is formed by a posttranslational, non-enzymatic, substrate-concentration dependent irreversible process of combination of aldehyde group of glucose and other hexoses with the amino-terminal valine of the beta-chain of hemoglobin. The estimation of GHb has provided a dependable method of assessing glycemic control in diabetics. We modified and established the chemical method of GHb estimation described by Fluckiger and Winterhalter based upon the generation of 5-hydroxymethylfurfural from the ketoamine by treatment with oxalic acid and reacting it with thiobarbituric acid to form a coloured adduct. This method has been extensively validated in diabetics as a reliable, inexpensive and non-manipulable parameter. In 48.7% of diabetics, metabolic control judged by GHb was discrepant from blood glucose; 63% of patients showing, discrepant values seemed to diet better on the day of test to produce a better blood glucose value. We have critically reviewed the other methods of GHb estimation. We studied the rate of dissipation of GHb in a group of newly diagnosed type 2 diabetics in whom blood glucose was lowered steadily by using glipizide. We found that lowering of GHb at 2, 4, 6, 8, 10 weeks of treatment was 1.0, 0.7, 0.5, 0.5, and 0.1 per cent respectively. This fact has subsequently been corroborated by-other investigators. A large number of kinetic studies have revealed that glycemia in the recent past influences the GHb values more than the remote past. Thus, mean blood glucose of past 1 month, 2 months and 3 months,contributes 50%, 40% and 10% respectively to the final result. Though the role of GHb is established in monitoring control of diabetes, its role in diagnosis of diabetes still remains questionable. We. have demonstrated increased glycation in impaired glucose tolerance and stress hyperglycemia, thus indicating that these groups need to be treated. We have correlated GHb with the degree of hemolysis in patients of hemolytic anemias. GHb was significantly lower:in patients of hemolytic anemia as compared to anemia of other etiologies and had a significant. positive correlation (r = 0.69; P < 0.001) with erythrocyte half-life.
机译：糖化血红蛋白（GHb）是由翻译后的，非酶促的，底物浓度依赖性的葡萄糖和其他己糖的醛基与血红蛋白β链的氨基末端缬氨酸结合而成的不可逆过程形成的。 GHb的估计提供了评估糖尿病患者血糖控制的可靠方法。我们修改并建立了Fluckiger和Winterhalter描述的GHb估算的化学方法，该方法基于通过用草酸处理并从酮胺中生成5-羟甲基糠醛并使之与硫代巴比妥酸反应形成有色加合物。该方法已在糖尿病患者中被广泛验证为一种可靠，廉价且不可操作的参数。在48.7％的糖尿病患者中，GHb判断出的代谢控制与血糖不符。 63％表现出差异的患者似乎在测试当天节食更好，以产生更好的血糖值。我们已经严格审查了GHb估计的其他方法。我们研究了一组新诊断的2型糖尿病患者中GHb的耗散率，其中使用格列吡嗪使血糖稳定地降低。我们发现，在治疗2、4、6、8、10周时GHb的降低分别为1.0％，0.7％，0.5％，0.5％和0.1％。随后，其他调查人员证实了这一事实。大量的动力学研究表明，最近的血糖对GHb值的影响比遥远的过去更大。因此，过去1个月，2个月和3个月的平均血糖分别占最终结果的50％，40％和10％。尽管已经确定了GHb在监测糖尿病控制中的作用，但其在糖尿病诊断中的作用仍然值得怀疑。我们。已经证明糖化增加可导致葡萄糖耐量降低和应激性高血糖症，因此表明这些组需要治疗。我们已经将GHb与溶血性贫血患者的溶血程度相关联。 GHb明显较低：与其他病因性贫血相比，溶血性贫血患者的GHb显着降低。与红细胞半衰期呈正相关（r = 0.69; P <0.001）。

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