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首页> 外文期刊>Polyhedron: The International Journal for Inorganic and Organometallic Chemistry >Syntheses, spectra, photoinduced nitric oxide release and interactions with biomacromolecules of three nitrosylruthenium complexes
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Syntheses, spectra, photoinduced nitric oxide release and interactions with biomacromolecules of three nitrosylruthenium complexes

机译：合成，光谱，光致一氧化氮释放和三种亚硝基钌配合物的生物致摩托族的相互作用

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摘要

Three nitrosylruthenium complexes, [RuCl(qn)L(NO)] (qn = 8-hydroxyquinoline; L = L-Asp, L-Lys and picp), have been synthesized. The photodynamic reactions of the three complexes were analyzed with time resolved FTIR spectroscopy and the photoinduced release of NO was confirmed by EPR via spin trapping of the NO free radical. The binding constants of the complexes with calf thymus DNA and human serum albumin were quantitatively determined by fluorescence spectroscopy, with a stronger binding being found for the [RuCl(qn)(picp)(NO)] (picp = 2-(4-carboxylphenyl)-imidazolium[4,5-f][1,10] phenanthroline) complex compared to the other two complexes. Photoirradiation of the complexes mixed with HSA solution resulted in a blue-shift of the vibrational frequency of NO and an increased amount of released NO. The cell toxicity of the complexes was screened to understand the effects of the different ligands on the biological activity of the Ru complexes. The [RuCl(qn)(picp)(NO)] complex showed better activity against the HepG-2 cell, with an IC50 value of 24.9 mu M without light and 13.8 mu M upon photoirradiation. Moreover, a comparison of photoinduced DNA cleavage and photodynamic cellular toxicity suggests the important role of the NO free radical. This study provides a strategy for the design of NO-donors and the potential application of Ru-NO complexes in photodynamic therapy. (C) 2020 Elsevier Ltd. All rights reserved.
机译：已经合成了三种亚硝基钌络合物，[RuCl（QN）L（NO）]（QN = 8-羟基喹啉; L = L-ASP，L-LY和PICP）。用时间分辨的FTIR光谱分析三个配合物的光动力反应，并通过EPR通过旋转捕获的无自由基来确认NO的光导释放。通过荧光光谱定量用荧光光谱定量测定与小牛胸腺DNA和人血清白蛋白的结合常数，用于[RuCl（QN）（PICP）（NO）]（3-羧基苯基） - 与其他两个配合物相比，咪唑鎓[4,5-F] [1,10]菲咯啉。与HSA溶液混合的复合物的光放射导致振动频率的蓝移，释放的释放量增加。筛选复合物的细胞毒性以了解不同配体对Ru复合物的生物活性的影响。 [RuCl（QN）（PICP）（NO）]复合物对HEPG-2细胞显示出更好的活性，IC50值24.9μm，没有光和光放射的13.8μm。此外，光诱导的DNA裂解和光动力细胞毒性的比较表明No自由基的重要作用。本研究提供了无捐赠者设计的策略和ru-no复合物在光动力疗法中的潜在应用。 （c）2020 elestvier有限公司保留所有权利。

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  • 作者

    Song Luna; Xie Leilei; Xu Liqun; Jing Qi; Liu Chenyang; Xi Xiaoli; Wang Wenming; Zhao Yi; Zhao Xuan; Wang Hongfei;

  • 作者单位

    Shanxi Univ Inst Mol Sci Educ Minist Key Lab Chem Biol &

    Mol Engn Taiyuan 030006 Peoples R China;

    Shanxi Univ Inst Mol Sci Educ Minist Key Lab Chem Biol &

    Mol Engn Taiyuan 030006 Peoples R China;

    Shanxi Univ Inst Mol Sci Educ Minist Key Lab Chem Biol &

    Mol Engn Taiyuan 030006 Peoples R China;

    Shanxi Univ Inst Mol Sci Educ Minist Key Lab Chem Biol &

    Mol Engn Taiyuan 030006 Peoples R China;

    Shanxi Univ Inst Mol Sci Educ Minist Key Lab Chem Biol &

    Mol Engn Taiyuan 030006 Peoples R China;

    Shanxi Univ Inst Mol Sci Educ Minist Key Lab Chem Biol &

    Mol Engn Taiyuan 030006 Peoples R China;

    Shanxi Univ Inst Mol Sci Educ Minist Key Lab Chem Biol &

    Mol Engn Taiyuan 030006 Peoples R China;

    Biol Inst Shanxi Taiyuan 030006 Peoples R China;

    Univ Memphis Dept Chem Memphis TN 38152 USA;

    Shanxi Univ Inst Mol Sci Educ Minist Key Lab Chem Biol &

    Mol Engn Taiyuan 030006 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 无机化学;
  • 关键词

    Ruthenium complex; Nitrosyl; Cytotoxicity; Photodynamic; Biomacromolecules;

    机译：钌络合物;亚硝基;细胞毒性;光动力学;生物致摩托;

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