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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Improvement in the efficacy of existing combination of antifilarials by inclusion of tetracycline in rodent model of Brugian filariasis
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Improvement in the efficacy of existing combination of antifilarials by inclusion of tetracycline in rodent model of Brugian filariasis

机译：通过将四环素纳入布鲁日丝虫病的啮齿动物模型中，提高现有抗疟药组合的疗效

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Newer control strategies like combination drug therapy have proved effective against a variety of pathogens, including filarial parasites. The recent discovery of Wolbachia, a bacterial endosymbiont present in the filarial parasites, dependence of parasites on the bacteria for their own survival, and fecundity and bacterial sensitivity to tetracycline have given new hope to the ongoing antifilarial drug development programme, especially in view of the conflicting combination field trial results obtained from various geographical regions. The present studies were therefore planned to investigate whether adding tetracycline to the already recommended combinations of antifilarials would lead to further improved antifilarial efficacy in terms of killingof adult worms or their sterilization. The present study therefore employs the Brugia malayilMastomys concha model in order to extrapolate the findings in human filarial patients. Different combinations were used and all of these proved to exert greatermicro and macrofilaricidal action. The best combination (di-ethylcarbamazine + ivermectin + albendazole) exerted remarkable macrofilaricidal efficacy (63%), sterilized all the surviving female parasites and completely eliminated microfilariae from the peripheral blood on day 90 post-treatment. Tetracycline enhanced the em-bryostatic action of all the filaricides, although it alone did not demonstrate any significant embryostatic efficacy when administered for five consecutive days. The present findingsthus strongly suggest the limited clinical trial of tetracycline in combination with the standard filaricides.
机译：新型的控制策略（如联合药物疗法）已被证明可有效对抗多种病原体，包括丝虫。最近发现的Wolbachia（一种存在于丝状寄生虫中的细菌内共生体），寄生虫对细菌自身生存的依赖性以及对四环素的繁殖力和细菌敏感性给正在进行的抗丝虫药物开发计划带来了新的希望，尤其是鉴于从各个地理区域获得的相互矛盾的组合田间试验结果。因此，本研究计划调查是否将四环素添加到已经推荐的抗丝虫剂组合中是否会导致杀灭成虫或对其灭菌的抗丝虫剂功效进一步提高。因此，本研究采用Brugia malayilMastomys外耳模型来推断人类丝虫病患者的发现。使用了不同的组合，并且所有这些都被证明可以发挥更大的微杀虫作用。最佳组合（二乙基卡巴嗪+伊维菌素+阿苯达唑）发挥了显着的大丝杀虫效力（63％），对所有存活的女性寄生虫进行了灭菌，并在治疗后第90天彻底清除了外周血中的微丝虫病。四环素增强了所有杀线虫剂的抑胚作用，尽管当连续服用五天时，单独使用它并没有显示出任何明显的抑胚作用。目前的发现强烈表明四环素与标准杀线虫剂联合使用的临床试验有限。

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