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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >'Key regulators of the cell cycle': 2001 Nobel Prize for Physiology or Medicine
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'Key regulators of the cell cycle': 2001 Nobel Prize for Physiology or Medicine

机译：“细胞周期的关键调节剂”：2001年诺贝尔生理学或医学奖

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摘要

During the last three decades, significant progress has been made in our understanding of the regulatory control of step-wise progression of cell-division cycle, that involves alternation between chromosome segregation (anaphase separation of chromosomes) and chromosome duplication (DNA synthesis). The importance of this work for human health care has been recognized by the award of the centenary Nobel Prize for Medicine or Physiology for the year 2001 to three scientists [Timothy (Tim) Hunt, FRS and Sir Paul Nurse, FRS of The Imperial Cancer Research Fund, London and Leland (Lee) Hartwell of the Fred Hutchinson Cancer Research Center, Seattle, USA]. Paul Nurse and Lee Hartwell were also among the seven recipients of the 1998 Albert Lasker Medical Research Award, which is considered as an indicator of a future Nobel Prize for Physiology or Medicine. This year's Nobel Prize-winning discoveries are particularly important in understanding how disturbances within a cell at the sub-cellular and molecular level may lead to the development of cancer cells (cells with uncontrolled cell-division). An excellent and a fairly up-to-date account of the regulation of cell-division cycle is available in the third edition of the book Molecular Biology of the Cell, published in 1994 (ref. 1). A brief summary of molecular basis of the regulation of cell-division cycle is also available in the author's book Cytology, Genetics and Evoution, written for undergradute students and a relatively more detailed account is available in the author's other two textbooks, Genetics and Cell and Molecular Biology, both written for honours and postgraduate students. Several reviews, some of them written by this year's Nobel Prize winners, are also available on the subject.
机译：在过去的三十年中，在我们对细胞分裂周期逐步进展的调控控制的理解上取得了重大进展，这涉及染色体分离（染色体的后期分离）和染色体复制（DNA合成）之间的交替。 2001年诺贝尔医学奖或生理学奖授予三位科学家[蒂莫西·亨特（Timothy Hunt），FRS和保罗·奈瑟（Paul Nurse）爵士，帝国癌症研究（IRS）基金会，伦敦和美国西雅图弗雷德·哈钦森癌症研究中心的利兰（Lee）Hartwell]。保罗·奈瑟（Paul Nurse）和李·哈特威尔（Lee Hartwell）也是1998年阿尔伯特·拉斯克医学研究奖的七位获奖者，该奖被认为是未来诺贝尔生理学或医学奖的一个指标。今年的诺贝尔奖获奖发现对于理解细胞在亚细胞和分子水平的干扰如何导致癌细胞（细胞分裂不受控制的细胞）的发展特别重要。 1994年出版的《细胞分子生物学》第三版（参考文献1）中提供了关于细胞分裂周期调控的出色且相当最新的说明。作者的书《细胞学，遗传学和进化论》（Cytology，Genetics and Evoution）是为本科生而写的，它对调节细胞分裂周期的分子基础作了简要概述，而作者的另外两本教科书《 Genetics and Cell and分子生物学，既是为荣誉而写的，也是为研究生而写的。关于此主题，还提供了一些评论，其中一些是由今年的诺贝尔奖获得者撰写的。

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