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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >High-mobility-group chromosomal proteins, HMGA1 as potential tumour markers [Review]
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High-mobility-group chromosomal proteins, HMGA1 as potential tumour markers [Review]

机译：高迁移率族染色体蛋白HMGA1作为潜在的肿瘤标志物[综述]

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摘要

The high-mobility-group, HMGA1 (formerly HMG I/Y) family of non-histone, chromosomal proteins consisting of HMGA1a, HMGA1b and HMGA2 are known as 'architectural transcription factors' because of their specific protein-protein and protein-DNA interactions. In the recent past, the HMGA1 family has got special attention and has been given several names like 'oncoproteins', 'enhancers', 'multifunctional proteins', 'architectural elements', 'tumour markers', etc. The increased interest in the last few years in these small molecular weight proteins is due to their high expression in neoplastic transformation of cells and metastatic tumour progression. Because of their elevated levels found in a wide variety of human cancers, they are suggested as novel diagnostic tumour markers. These proteins have three conserved binding domains called 'AT-hooks' which bind to the narrow minor groove of the DNA in the AT-rich sequences and bring conformational changes in DNA and chromatin. They are also known to participate in protein-protein interaction in the organization of transcriptional complex and assembly of 'enhanceosome'. Since HMGA1 proteins are the only oncoproteins known so far, which bind to the DNA minor groove, they are also used as potential targets for anti-tumour drugs.
机译：非组蛋白，由HMGA1a，HMGA1b和HMGA2组成的染色体蛋白的高迁移率族HMGA1（以前为HMG I / Y）家族因其特定的蛋白质-蛋白质和蛋白质-DNA相互作用而被称为“建筑转录因子” 。最近，HMGA1家族受到了特别的关注，并被赋予了多个名称，例如“癌蛋白”，“增强子”，“多功能蛋白”，“建筑元素”，“肿瘤标志物”等。这些小分子量蛋白质中的几年是由于它们在细胞的肿瘤转化和转移性肿瘤进展中的高表达。由于它们在多种人类癌症中的水平升高，因此被建议作为新型的诊断性肿瘤标志物。这些蛋白质具有三个保守的结合结构域，称为“ AT-钩子”，它们与富含AT的序列中DNA的狭窄小沟结合并带来DNA和染色质的构象变化。还已知它们在转录复合物的组织和“增强体”的组装中参与蛋白质-蛋白质相互作用。由于HMGA1蛋白是迄今为止已知的唯一与DNA小沟结合的癌蛋白，因此它们也可用作抗肿瘤药物的潜在靶标。

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