...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Science: A Fortnightly Journal of Research >A molecular voltmeter: Solution to a fifty-year-old puzzle?
【24h】

A molecular voltmeter: Solution to a fifty-year-old puzzle?

机译：分子电压表：一个五十年前的难题的解决方案？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

These are the best of times for membrane biologists with a surge of interest in membrane proteins and processes, and an ever-increasing number of techniques coming to bear on all matters membranous. These are the worst of times for membrane biologists with the disparity between the number of structures of soluble and membrane proteins solved growing to three orders of magnitude and counting. The voltage-gated K~+ channel is now perhaps the best studied membrane protein, with a variety of techniques mapping aspects of function onto specific portions of the sequence. However, an understanding of how the protein senses transmembrane potential and transduces changes in potential into channel opening requires a three-dimensional structure. This has now been provided by the recent structures of the archaebacterial channel KvAP reported by Rod MacKinnon's group.
机译：对于膜生物学家来说，这是最好的时机，对膜蛋白和膜工艺的兴趣激增，并且涉及膜的所有问题的技术越来越多。对于膜生物学家来说，这是最糟糕的时期，溶解的可溶性蛋白和膜蛋白的结构数量之间的差异增长到三个数量级并计数。电压门控的K +通道现在可能是研究最深入的膜蛋白，它采用多种技术将功能的各个方面映射到序列的特定部分。然而，对蛋白质如何感测跨膜电位并将电位的变化转导至通道开放的理解需要三维结构。 Rod MacKinnon研究小组报告的古细菌通道KvAP的最新结构已提供了这一点。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号