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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Enhancement of cytotoxicity and DNA binding of cisplatin in Dalton's lymphoma cells by alpha -tocopherol
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Enhancement of cytotoxicity and DNA binding of cisplatin in Dalton's lymphoma cells by alpha -tocopherol

机译：α-生育酚增强道尔顿淋巴瘤细胞的顺铂细胞毒性和DNA结合

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摘要

A combination treatment of cisplatin and alpha -tocopherol on Dalton's lymphoma cells in vitro was studied in order to examine the effect of alpha -tocopherol on cisplatin cytotoxicity and binding of platinum to DNA (DNA platination) or its removal from DNA. Cisplatin cytotoxicity which is measured as cell survival of Dalton's lymphoma cells was found to be enhanced by various factors, including concentration of drug, treatment duration and presence of alpha -tocopherol in the medium. Tumour cells treated with increasing concentrations of cisplatin or cisplatin with alpha -tocopherol lower cell survival and increase DNA platination. There was a significant correlation between percentage survival of Dalton's lymphoma cells and DNA platination. The study of percentage removal of platinum has shown an inverse linear correlation between DNA damage and DNA repair. The enhanced cytotoxicity of cisplatin by alpha -tocopherol could be attributed to increased platinum binding to DNA, which might decrease DNA repair.
机译：为了研究α-生育酚对顺铂细胞毒性和铂与DNA结合（DNA电镀）或从DNA去除的作用，研究了顺铂和α-生育酚对道尔顿淋巴瘤细胞的体外联合治疗。发现以道尔顿淋巴瘤细胞的细胞存活率衡量的顺铂细胞毒性可通过多种因素增强，包括药物浓度，治疗持续时间和培养基中α-生育酚的存在。用增加浓度的顺铂或具有α-生育酚的顺铂处理的肿瘤细胞降低细胞存活率并增加DNA平台化。道尔顿淋巴瘤细胞的存活百分率与DNA平板化之间存在显着的相关性。铂去除百分率的研究表明，DNA损伤与DNA修复之间呈反线性关系。 α-生育酚增强顺铂的细胞毒性可归因于铂与DNA的结合增加，这可能会减少DNA修复。

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