• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Structure and function of inositol 1,4,5-trisphosphate receptors
【24h】

Structure and function of inositol 1,4,5-trisphosphate receptors

机译：肌醇1,4,5-三磷酸受体的结构和功能

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The InsP_3R is an intracellular calcium release channel that forms an important component of the InsP_3 signalling pathway and is ubiquitously expressed in mul-ticellular organisms. Molecular studies have identified three separate genes in mammals that code for the three isoforms of InsP_3Rs. These three isoforms are shown to have different ligand affinities and modulatory properties. These differences are presently thought to generate the heterogeneity required in calcium dynamics to regulate processes as diverse as secretion, synaptic plasticity, immune responses in T cells and fertilization events in sea urchin eggs. The understanding of these processes mandates an understanding of the single channel properties of the three isoforms as well as splice variants that are expressed in a tissue-specific manner. Recent single channel studies aimed at understanding the functional properties of the InsP_3Rs using point mutants in the channel havg uncovered important residues that affect the calcium dependence and ion selectivity of the channel. Genetic studies using knockouts of the mammalian InsP_3Rs appear inadequate to relate the channel function to the physiological behaviour at an animal level most likely due to compensation by other isoforms of the channel. In this scenario, study of InsP_3R in Drosophila melanogaster, that encodes a single gene for InsP_3R should prove useful in correlating single channel properties of the channel with phenotypes of the whole organism.
机译：InsP_3R是形成InsP_3信号通路重要组成部分的细胞内钙释放通道，并在多细胞生物中普遍表达。分子研究已在哺乳动物中鉴定出三个独立的基因，它们编码InsP_3Rs的三个同工型。显示这三个同工型具有不同的配体亲和力和调节特性。目前认为这些差异产生钙动力学所需的异质性，以调节各种过程，例如分泌，突触可塑性，T细胞中的免疫反应和海胆卵受精事件。对这些过程的理解要求对三种同工型以及以组织特异性方式表达的剪接变体的单通道特性的理解。最近的单通道研究旨在使用通道havg中的点突变体了解InsP_3R的功能特性，发现了影响通道的钙依赖性和离子选择性的重要残基。使用哺乳动物InsP_3R的基因敲除进行的遗传研究似乎不足以将通道功能与动物水平的生理行为相关联，这很可能是由于通道的其他同工型所引起的。在这种情况下，研究果蝇中编码InsP_3R单个基因的InsP_3R有助于将通道的单通道特性与整个生物体的表型相关联。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号