Raman spectroscopy of stored red blood cell concentrate within sealed transfusion blood bags

Vardaki M. Z.; Atkins C. G.; Schulze H. G.; Devine D. V.; Serrano K.; Blades M. W.; Turner R. F. B.

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Raman spectroscopy of stored red blood cell concentrate within sealed transfusion blood bags

机译：储存红细胞的拉曼光谱分子浓缩在密封输血血袋内

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The standard practice in blood banks worldwide involves storage of red blood cells (RBCs) in plastic bags until they are needed for transfusion. During storage, the cells gradually degrade in functionality, a condition described as RBC storage lesion. Standard analytical techniques cannot assess the blood quality without breaching the sterility of the transfusion bag. In this study, we employed a commercially available spatially offset Raman spectroscopy (SORS) system using a custom designed protocol to non-invasively explore the biochemical changes in RBC concentrate of healthy donors over a storage period of approximately 42 days in standard transfusion bags, under standard storage conditions. The results reveal an increase in the oxygenation state of haemoglobin over the storage period for all donors, but different profiles for each donor. This study demonstrates the feasibility of acquiring consistent biochemical information relevant to the quality of stored blood, in situ through sealed blood transfusion bags using a commercially available instrument.

机译：全世界血库的标准做法涉及在塑料袋中储存红细胞（RBC），直到它们需要输血。在储存期间，细胞逐渐逐渐降低功能性，该条件描述为RBC储存病变。标准分析技术不能评估血液质量而不违反输血袋的无菌性。在这项研究中，我们采用了一种可商购的空间偏移拉曼光谱（SORS）使用定制设计的协议来系统非侵入性地探索在健康供体的RBC浓缩物超过在标准输血袋约42天的储存期的生物化学变化，下标准储存条件。结果揭示了所有供体的储存期内血红蛋白氧合状态的增加，但每个供体的不同曲线。本研究表明，使用市售仪器获得与储存血液质量相关的一致生化信息的可行性。

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《The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry》 |2018年第24期|共8页
作者
Vardaki M. Z.; Atkins C. G.; Schulze H. G.; Devine D. V.; Serrano K.; Blades M. W.; Turner R. F. B.;
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Univ British Columbia Michael Smith Labs 2185 East Mall Vancouver BC V6T IZ4 Canada;

Univ British Columbia Michael Smith Labs 2185 East Mall Vancouver BC V6T IZ4 Canada;

Univ British Columbia Michael Smith Labs 2185 East Mall Vancouver BC V6T IZ4 Canada;

Univ British Columbia Dept Pathol &

Lab Med 2211 Wesbrook Mall Vancouver BC V6T 2B5 Canada;

Univ British Columbia Dept Pathol &

Lab Med 2211 Wesbrook Mall Vancouver BC V6T 2B5 Canada;

Univ British Columbia Dept Chem 2036 Main Mall Vancouver BC V6T IZ1 Canada;

Univ British Columbia Michael Smith Labs 2185 East Mall Vancouver BC V6T IZ4 Canada;

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正文语种 eng
中图分类分析化学;
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1. Raman spectroscopy of stored red blood cell concentrate within sealed transfusion blood bags [J] . Vardaki M. Z., Atkins C. G., Schulze H. G., The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry . 2018,第24期

机译：储存红细胞的拉曼光谱分子浓缩在密封输血血袋内
2. Transfusion of fresh murine red blood cells reverses adverse effects of older stored red blood cells. [J] . Hendrickson JE, Hod EA, Hudson KE, Transfusion: The Journal of the American Association of Blood Banks . 2011,第12aPta1期

机译：新鲜鼠红细胞的输血逆转了旧储存的红细胞的不良影响。
3. The storage-lesion in murine red blood cells: comparison to stored human red blood cells and applications for an animal model of transfusion efficacy [J] . JE Jagger, I Chin-Yee, CG Ellis, Critical care : . 1999,第Suppla1期

机译：鼠红细胞中的储存病变：与储存的人红细胞的比较及其在输血功效动物模型中的应用
4. Raman spectroscopy of stored red blood cells: evaluating clinically relevant biochemical markers in donated blood [C] . Chad G. Atkins, Kevin Buckley, Deborah Chen, Clinical and biomedical spectroscopy and imaging IV . 2015

机译：储存的红细胞的拉曼光谱：评估献血中临床相关的生化标志物
5. Improving the Efficiency and Effectiveness of Chronic Blood Transfusions in the Hematology Clinic Using an Adaptive Algorithm Designed to Optimize Red Cell Use in Patients with Different Specific Transfusion Needs [D] . Medow, Joshua. 2019

机译：使用旨在优化不同特异性输血需求的患者优化红细胞使用的自适应算法，提高血液学诊所中慢性输血效率和有效性
6. Impaired Red Blood Cell Deformability After Transfusion of Stored Allogeneic Blood but not Autologous Salvaged Blood in Cardiac Surgery Patients [O] . Osman N. Salaria, Viachaslau M. Barodka, Charles W. Hogue, -1

机译：心脏手术患者输注储存的同种异体血液后红细胞变形能力受损但自体挽救性血液未受损
7. The storage-lesion in murine red blood cells: comparison to stored human red blood cells and applications for an animal model of transfusion efficacy [O] . Jagger, JE, Chin-Yee, I, Ellis, CG, 1999

机译：鼠红细胞中的储存病变：与储存的人红细胞的比较及其在输血功效动物模型中的应用
8. Standard Operating Procedure; Red Blood Cells Collected in the CPDA-1 800 ml Primary PVC Plastic Bag Collection System and Stored for 3 to 6 Days Prior to Glycerolization in the Primary 800 ml Bag Using 40% W/V Glycerol and Storage at -80 C, Washed in the Haemonetics Blood Processor 115, and Stored at 4 C for up to 24 Hours Prior to Transfusion [R] . 1997

机译：标准操作流程;将红细胞收集在CpDa-1 800 ml初级pVC塑料袋收集系统中，并在使用40％W / V甘油并在-80℃下储存的初级800ml袋中进行甘油化之前储存3至6天，在Haemonetics血液处理器115，输血前在4℃储存长达24小时

Raman spectroscopy of stored red blood cell concentrate within sealed transfusion blood bags

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