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首页> 外文期刊>The FEBS journal >Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7
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Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7

机译：人半乳糖素-7基于多价半乳糖的树突识别的结构基础

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摘要

Galectins are evolutionarily conserved and ubiquitously present animal lectins with a high affinity for beta-galactose-containing oligosaccharides. To date, 15 mammalian galectins have been identified. Their involvement in cell-cell and cell-matrix interactions has highlighted their importance in signal transduction and other intracellular processes. Human galectin-7 (hGal-7) is a 15 kDa proto type galectin that forms a dimer in solution and its involvement in the stimulation and development of tumour growth has been reported. Previously, we reported the crystal structure of hGal-7 and its complex with galactose and lactose which provided insight into its molecular recognition and detailed interactions. Here, we present newly obtained high-resolution structural data on carbohydrate-based dendrons in complex with hGal-7. Our crystallographic data reveal how multivalent ligands interact with and form cross-links with these galectin molecules. Understanding how these dendrimeric compounds interact with hGal-7 would help in the design of new tools to investigate the recognition of carbohydrates by lectins.
机译：半乳菌素正在进化地保守和普遍存在的动物凝集素，具有高亲和力的含β-半乳糖的寡糖。迄今为止，已经确定了15名哺乳动物的半乳糖菌素。它们参与细胞和细胞基质相互作用突出了它们在信号转导和其他细胞内方法中的重要性。人的Galectin-7（HGAL-7）是15kDa原型的半乳糖型，其在溶液中形成二聚体，并且据报道其刺激和发育肿瘤生长的刺激和发育。以前，我们报道了HGAL-7的晶体结构及其与半乳糖和乳糖的复合物，其提供了洞察其分子识别和详细的相互作用。在这里，我们在络合物与HGAL-7中以碳水化合物的树枝状的基于碳水化合物的树枝状的高分辨率结构数据提出新获得的高分辨率结构数据。我们的晶体数据揭示了多价配体与这些半乳糖型分子的交互性和形成交联。了解这些树枝状型化合物如何与HGAL-7相互作用将有助于设计新工具，以研究凝集素的核酸水合物的识别。

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