A guide to microRNA-mediated gene silencing

Huberdeau Miguel Quevillon; Simard Martin J.

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A guide to microRNA-mediated gene silencing

机译：microRNA介导的基因沉默指南

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摘要

As an important regulator of gene expression in eukaryotes, microRNAs (miRNAs) have been subject to extensive research to understand their pleiotropic roles in development and pathological processes. Here, we review strategies that have been developed to map microRNA-target interactions and the most effective methods to attribute post-transcriptional gene regulation through miRNA-mediated silencing. We further discuss the importance of the biological context for silencing.

机译：作为真核生物中基因表达的重要调节因子，MicroRNAS（MiRNA）一直受到广泛的研究，以了解他们在发育和病理过程中的肺炎作用。在这里，我们审查了已经开发的策略，以通过miRNA介导的沉默来映射MicroRNA-Tarmation相互作用和最有效的方法来将转录后基因调节归因于转录后基因调控。我们进一步讨论了沉默的生物学背景的重要性。

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《The FEBS journal》 |2019年第4期|共11页
作者
Huberdeau Miguel Quevillon; Simard Martin J.;
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作者单位

Univ Laval Res Ctr CHU Quebec Oncol Div St Patrick Res Grp Basic Oncol Quebec City PQ G1R 3S3 Canada;

Univ Laval Res Ctr CHU Quebec Oncol Div St Patrick Res Grp Basic Oncol Quebec City PQ G1R 3S3 Canada;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
gene regulation; microRNA target; microRNA target validation; miRISC;

机译：基因调节;microRNA目标;microRNA目标验证;Mirisc;

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专利

1. A guide to microRNA-mediated gene silencing [J] . Huberdeau Miguel Quevillon, Simard Martin J. The FEBS journal . 2019,第4期

机译：microRNA介导的基因沉默指南
2. Reversible male sterility in eggplant (Solanum melongena L.) by artificial microRNA-mediated silencing of general transcription factor genes [J] . Laura Toppino, Maarten Kooiker, Matias Lindner, Plant Biotechnology Journal . 2011,第6期

机译：通过人工微润罗纳介导的一般转录因子基因沉默的茄子（Solanum Melongena L.）的可逆雄性不育
3. MicroRNA 665 Regulates Dentinogenesis through MicroRNA-Mediated Silencing and Epigenetic Mechanisms [J] . Hannah M. Heair, Austin G. Kemper, Bhaskar Roy, Molecular and Cellular Biology . 2015,第18期

机译：MicroRNA 665通过MicroRNA介导的沉默和表观遗传机制调节牙本质生成。
4. Revealing the Functions of Glycosylation Genes in Breast Cancer Cell Brain Metastasis with Gene Silencing Coupled to LC-MS/MS Glycomics [C] . Wenjing Peng, Shiyue Zhou, Xue Dong, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：揭示糖基化基因在乳腺癌细胞脑转移中的功能与LC-MS / MS族的基因沉默
5. Broad transcript variability in the connexin gene family and microRNA-mediated translational regulation of Cx43 during myogenesis. [D] . Anderson, Curtis Lee. 2005

机译：连接蛋白基因家族中广泛的转录变异性和成肌过程中Cx43的microRNA介导的翻译调控。
6. MicroRNA 665 Regulates Dentinogenesis through MicroRNA-Mediated Silencing and Epigenetic Mechanisms [O] . Hannah M. Heair, Austin G. Kemper, Bhaskar Roy, 2015

机译：MicroRNA 665通过MicroRNA介导的沉默和表观遗传机制调节牙本质生成。
7. Reversible male sterility in eggplant (Solanum melongena L.) by artificial microRNA-mediated silencing of general transcription factor genes [O] . Laura Toppino, Maarten Kooiker, Matias Lindner, 2010

机译：通过人工微润罗纳介导的一般转录因子基因沉默的茄子（Solanum Melongena L.）的可逆雄性不育

A guide to microRNA-mediated gene silencing

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