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首页> 外文期刊>The FEBS journal >A guide to hyaluronan and related enzymes in breast cancer: biological significance and diagnostic value
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A guide to hyaluronan and related enzymes in breast cancer: biological significance and diagnostic value

机译：乳腺癌的乳腺癌和相关酶指南：生物意义和诊断价值

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abstract type="main" xml:id="febs14860-abs-0001" xml:lang="en"> p>Hyaluronan (HA) is a unique nonsulfated glycosaminoglycan that contributes to breast cancer cells growth and functional properties, including cell migration, invasion, adhesion, as well as tumor‐associated angiogenesis in different stages of breast cancer progression and especially metastasis. Latest data show that the levels of HA and/or low molecular mass HA in blood serum and plasma of breast cancer patients may be a useful biomarker for breast cancer prognosis, differential diagnosis, and patients' treatment monitoring. Therefore, the qualitative and quantitative determination of HA in biological samples is an emerging area of research. This review gathers, categorizes, and sums up all the currently used methodologies to analyze HA and HA‐related enzymes. The advantages, disadvantages, limitations in use, and the information they provide, are critically considered and discussed. Moreover, emphasis is given to the significance of HA determination in breast cancer, as well as of its related enzymes, for diagnosis and prognosis of this type of cancer./p> /abstract>
机译：＆抽象类型=“main”xml：id =“febs14860-abs-abs-0001”xml：lang =“en”> hyaluronan（ha）是一种独特的非硫酸糖胺聚糖，有助于乳腺癌细胞生长和功能性，包括细胞迁移，侵袭，粘附，以及乳腺癌进展的不同阶段的肿瘤相关血管生成，尤其是转移。最新数据表明，血清血清和患者血清血浆中HA和/或低分子量HA的水平可能是乳腺癌预后，鉴别诊断和患者治疗监测的有用生物标志物。因此，生物样本中HA的定性和定量测定是一种新兴的研究领域。此审查收集，分类，并汇总所有当前使用的方法来分析HA和HA相关酶。优点，缺点，使用限制以及它们提供的信息被批判性地考虑和讨论。此外，重点是HA测定在乳腺癌中的重要性，以及其相关酶，用于这种癌症的诊断和预后。＆ /摘要>

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