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首页> 外文期刊>The FEBS journal >Nicotine and the nicotinic cholinergic system in COVID-19
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Nicotine and the nicotinic cholinergic system in COVID-19

机译：尼古丁和Covid-19中的烟碱胆碱能系统

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摘要

There is an urgent need to address the devastating pandemic, COVID-19, caused by SARS-CoV-2. The efforts to understand the details of this disease in hope of providing effective treatments are commendable. It is clear now that the virus can cause far more damage in patients with comorbid conditions-particularly in those with respiratory, cardiovascular, or immune-compromised system-than in patients without such comorbidities. Drug use can further exacerbate the condition. In this regard, the ill effects of smoking are amply documented, and no doubt can be a confounding factor in COVID-19 progression. Although conflicting hypotheses on the potential role of nicotine in COVID-19 pathology have recently been offered, we believe that nicotine itself, through its interaction with the nicotinic cholinergic system, as well as ACE2, may not only be of use in a variety of neuropsychiatric and neurodegenerative diseases, but may also be of potential use in COVID-19. Thus, on one hand, while we strongly support smoking cessation as a means of harm reduction associated with COVID-19, on the other hand, we support a potential therapeutic role for nicotine, nicotinic agonists, or positive allosteric modulators of nicotinic cholinergic receptors in COVID-19, owing to their varied effects including mood regulation, anti-inflammatory, and purported interference with SARS-CoV-2 entry and/or replication.
机译：迫切需要解决由SARS-COV-2引起的毁灭性流行病，Covid-19。理解这种疾病细节的努力希望提供有效的治疗。现在很清楚，病毒可能会对合并症病症的患者造成更多伤害 - 特别是在没有这种合并症的患者中患有呼吸道，心血管或免疫受损的系统的患者。药物使用可以进一步加剧条件。在这方面，吸烟的不良影响是充分记录的，毫无疑问可以是Covid-19进展中的混淆因素。虽然最近提供了对尼古丁在Cocid-19病理中尼古丁的潜在作用的冲突，但我们认为尼古丁本身通过其与烟碱胆碱能系统的相互作用以及ACE2，可能不仅可以用于各种神经精神病症和神经变性疾病，但也可能在Covid-19中使用潜在使用。因此，一方面，我们强烈支持吸烟作为与Covid-19相关的伤害手段，另一方面，我们支持尼古丁，烟碱激动剂或烟碱胆碱能受体的阳性变构调节剂的潜在治疗作用Covid-19，由于其不同的效果，包括情绪调节，抗炎和声称干扰SARS-COV-2进入和/或复制。

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