The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the 'amyloid cascade hypothesis'

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The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the 'amyloid cascade hypothesis'

机译：在APP基因中发现阿尔茨海默蛋白突变和“淀粉样蛋白级联假设”的制剂

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The cloning of APP and genetic analysis of families with Alzheimer's disease were both reported in 1987 and much present work on the disease is based upon the foundations laid at that time. Progress was not smooth, however, and many errors were made. In this memoir, I lay out both the progress and the errors.

机译：1987年报告了对阿尔茨海默病的遗传和遗传分析的克隆，均报道了对该疾病的许多工作基于当时奠定的基础。然而，进展并不顺利，并进行了许多错误。在这个回忆录中，我铺设了进步和错误。

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《The FEBS journal》 |2017年第7期|共5页
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正文语种 eng
中图分类生物化学;
关键词
Alzheimer's disease; amyloid; APP; Down syndrome; genetics;

机译：阿尔茨海默病;淀粉样蛋白;app;唐氏综合征;遗传学;

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1. The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the "amyloid cascade hypothesis" [J] . The FEBS journal . 2017,第7期

机译：在APP基因中发现阿尔茨海默蛋白突变和“淀粉样蛋白级联假设”的制剂
2. Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease [J] . Barage Sagar H., Sonawane Kailas D. Neuropeptides: An International Journal . 2015,第Null期

机译：淀粉样蛋白级联假说：阿尔茨海默氏病的发病机制和治疗策略
3. Advances in the pathogenesis of Alzheimer’s disease: a re-evaluation of amyloid cascade hypothesis [J] . Suzhen Dong, Yale Duan, Yinghe Hu, Translational Neurodegeneration . 2012,第1期

机译：阿尔茨海默氏病发病机理的研究进展：对淀粉样蛋白级联假说的重新评估
4. Combining Mutation and Gene Network Data in a Machine Learning Approach for False-Positive Cancer Driver Gene Discovery [C] . Jorge Francisco Cutigi, Renato Feijo Evangelista, Rodrigo Henrique Ramos, Brazilian Symposium on Bioinformatics . 2020

机译：在机器学习方法中结合突变和基因网络数据，用于假冒癌症驾驶员基因发现
5. Gene discovery and function: Characterization of two embryonic lethal mutations induced by gene entrapment in mice [D] . Williamson, Douglas John 2000

机译：基因发现和功能：小鼠基因诱捕引起的两个胚胎致死突变的表征
6. The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis? [O] . Pierre Dourlen, Devrim Kilinc, Nicolas Malmanche, -1

机译：阿尔茨海默氏病的新遗传格局：从淀粉样蛋白级联反应到遗传驱动的突触衰竭假说？
7. The discovery of Alzheimer‐causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis” [O] . John Hardy 2017

机译：在APP基因中发现阿尔茨海默蛋白突变和“淀粉样蛋白级联假设”的制剂

The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the 'amyloid cascade hypothesis'

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